Long-lasting hormonal alterations to extreme stress in humans: Normative or maladaptive?

R. Yehuda, H. Resnick, B. Kahana, E. L. Giller

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

The biological consequences of stress have been studied for over half a decade, however, little is known about persistent biological alterations after extreme stress in humans. Posttraumatic stress disorder (PTSD) is a syndrome that occurs in some individuals after exposure to extreme stress. In this review, we summarize some of our studies of hypothalamic-pituitary- adrenal axis alterations in PTSD and compare and contrast these findings with knowledge concerning biological changes following stress.

Original languageEnglish
Pages (from-to)287-297
Number of pages11
JournalPsychosomatic Medicine
Volume55
Issue number3
DOIs
StatePublished - 1993
Externally publishedYes

Keywords

  • HPA axis
  • PTSD
  • cortisol

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