Abstract
Inference on binary outcomes is a common goal in clinical trials and case-control studies. Logistic regression is the usual approach to estimate treatment effect adjusted for categorical and continuous confounding variables. In this chapter, model building, interpretation of parameters, diagnostics, and inference to small sample sizes are discussed. At last, a case study is presented applying the proposed analytic strategies.
Original language | English |
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Title of host publication | Principles and Practice of Clinical Trials |
Publisher | Springer International Publishing |
Pages | 1789-1811 |
Number of pages | 23 |
ISBN (Electronic) | 9783319526362 |
ISBN (Print) | 9783319526355 |
DOIs | |
State | Published - 1 Jan 2022 |
Externally published | Yes |
Keywords
- Binary response
- Case-control study
- Cohort studies
- Odds ratio