Location, location, location: B-cell differentiation in the gut lamina propria

A. Cerutti

doi:10.1038/mi.2007.8

Location, location, location: B-cell differentiation in the gut lamina propria

A. Cerutti

Research output: Contribution to journal › Comment/debate

52 Scopus citations

Abstract

The intestinal immune system includes an immunoglobulin (Ig)A-inductive site represented by Peyer's patches (PPs) and an IgA effector site represented by the lamina propria (LP). This canonical map of intestinal IgA production has been blurred recently by studies showing the presence of active IgA class switching in the LP. Here we discuss the functional implications and controversial nature of these findings.

Original language	English
Pages (from-to)	8-10
Number of pages	3
Journal	Mucosal Immunology
Volume	1
Issue number	1
DOIs	https://doi.org/10.1038/mi.2007.8
State	Published - Jan 2008
Externally published	Yes

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10.1038/mi.2007.8

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title = "Location, location, location: B-cell differentiation in the gut lamina propria",

abstract = "The intestinal immune system includes an immunoglobulin (Ig)A-inductive site represented by Peyer's patches (PPs) and an IgA effector site represented by the lamina propria (LP). This canonical map of intestinal IgA production has been blurred recently by studies showing the presence of active IgA class switching in the LP. Here we discuss the functional implications and controversial nature of these findings.",

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AB - The intestinal immune system includes an immunoglobulin (Ig)A-inductive site represented by Peyer's patches (PPs) and an IgA effector site represented by the lamina propria (LP). This canonical map of intestinal IgA production has been blurred recently by studies showing the presence of active IgA class switching in the LP. Here we discuss the functional implications and controversial nature of these findings.

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Location, location, location: B-cell differentiation in the gut lamina propria

Abstract

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