Localized scleroderma: A clinical review

Mark Tratenberg, Farrah Gutwein, Varuni Rao, Kirk Sperber, Amy Wasserman, Julia Ash

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

Localized scleroderma (LS) is characterized by excessive collagen deposition leading to thickening of the dermis, subcutaneous tissue or both. The outcome for most patients with localized scleroderma is directly related to the type and stage of the affected tissue. The major challenge for untreated patients is not increased mortality risk, rather deformity and growth defects from skin, muscle and bone abnormalities. Treatment is individualized to type and stage of the lesion and may include pharmacologic and non-pharmacologic therapies. Among the pharmacologic modalities, methotrexate with systemic glucocorticoids is currently the mainstay of treatment. More controlled trials are needed to determine the length of treatment and the maintenance dose of this combination therapy.

Original languageEnglish
Pages (from-to)86-92
Number of pages7
JournalCurrent Rheumatology Reviews
Volume13
Issue number2
DOIs
StatePublished - 1 Aug 2017
Externally publishedYes

Keywords

  • En-coup de sabre
  • Guttate
  • Keloid
  • Linear
  • Morphea
  • Non-pharmacologic therapies
  • Scleroderma

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