Localization of the human stem cell tyrosine kinase-1 gene (FLT3) to 13q12→q13

C. E. Carow; E. Kim; A. L. Hawkins; H. D. Webb; C. A. Griffin; E. W. Jabs; C. I. Civin; Donald Small

doi:10.1159/000134046

Localization of the human stem cell tyrosine kinase-1 gene (FLT3) to 13q12→q13

C. E. Carow, E. Kim, A. L. Hawkins, H. D. Webb, C. A. Griffin, E. W. Jabs, C. I. Civin, Donald Small

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

We have previously reported the cloning of stem cell tyrosine kinase-1 (STK-1, gene symbol FLT3), the human homolog of the mouse Flk2/Flt3 gene (Small et al., 1994). This growth factor receptor is expressed in CD34⁺ human bone marrow (stem/progenitor) cells. We have mapped the gene for STK-1 using PCR screening of a human-rodent somatic cell hybrid panel, and fluorescence in situ molecular hybridization (FISH) of STK-1 genomic probes to mitotic chromosomes of normal human lymphocytes. The results of both analyses show that the gene for STK-1 (FLT3) localizes to chromosome 13q12→q13.

Original language	English
Pages (from-to)	255-257
Number of pages	3
Journal	Cytogenetics and Cell Genetics
Volume	70
Issue number	3-4
DOIs	https://doi.org/10.1159/000134046
State	Published - 1995
Externally published	Yes

Access to Document

10.1159/000134046

Cite this

@article{13addfa3527f414a8796a07ca541e0ef,

title = "Localization of the human stem cell tyrosine kinase-1 gene (FLT3) to 13q12→q13",

abstract = "We have previously reported the cloning of stem cell tyrosine kinase-1 (STK-1, gene symbol FLT3), the human homolog of the mouse Flk2/Flt3 gene (Small et al., 1994). This growth factor receptor is expressed in CD34+ human bone marrow (stem/progenitor) cells. We have mapped the gene for STK-1 using PCR screening of a human-rodent somatic cell hybrid panel, and fluorescence in situ molecular hybridization (FISH) of STK-1 genomic probes to mitotic chromosomes of normal human lymphocytes. The results of both analyses show that the gene for STK-1 (FLT3) localizes to chromosome 13q12→q13.",

author = "Carow, \{C. E.\} and E. Kim and Hawkins, \{A. L.\} and Webb, \{H. D.\} and Griffin, \{C. A.\} and Jabs, \{E. W.\} and Civin, \{C. I.\} and Donald Small",

year = "1995",

doi = "10.1159/000134046",

language = "English",

volume = "70",

pages = "255--257",

journal = "Cytogenetics and Cell Genetics",

issn = "0301-0171",

publisher = "S. Karger AG",

number = "3-4",

}

TY - JOUR

T1 - Localization of the human stem cell tyrosine kinase-1 gene (FLT3) to 13q12→q13

AU - Carow, C. E.

AU - Kim, E.

AU - Hawkins, A. L.

AU - Webb, H. D.

AU - Griffin, C. A.

AU - Jabs, E. W.

AU - Civin, C. I.

AU - Small, Donald

PY - 1995

Y1 - 1995

N2 - We have previously reported the cloning of stem cell tyrosine kinase-1 (STK-1, gene symbol FLT3), the human homolog of the mouse Flk2/Flt3 gene (Small et al., 1994). This growth factor receptor is expressed in CD34+ human bone marrow (stem/progenitor) cells. We have mapped the gene for STK-1 using PCR screening of a human-rodent somatic cell hybrid panel, and fluorescence in situ molecular hybridization (FISH) of STK-1 genomic probes to mitotic chromosomes of normal human lymphocytes. The results of both analyses show that the gene for STK-1 (FLT3) localizes to chromosome 13q12→q13.

AB - We have previously reported the cloning of stem cell tyrosine kinase-1 (STK-1, gene symbol FLT3), the human homolog of the mouse Flk2/Flt3 gene (Small et al., 1994). This growth factor receptor is expressed in CD34+ human bone marrow (stem/progenitor) cells. We have mapped the gene for STK-1 using PCR screening of a human-rodent somatic cell hybrid panel, and fluorescence in situ molecular hybridization (FISH) of STK-1 genomic probes to mitotic chromosomes of normal human lymphocytes. The results of both analyses show that the gene for STK-1 (FLT3) localizes to chromosome 13q12→q13.

UR - https://www.scopus.com/pages/publications/0029035716

U2 - 10.1159/000134046

DO - 10.1159/000134046

M3 - Article

C2 - 7789184

AN - SCOPUS:0029035716

SN - 0301-0171

VL - 70

SP - 255

EP - 257

JO - Cytogenetics and Cell Genetics

JF - Cytogenetics and Cell Genetics

IS - 3-4

ER -

Localization of the human stem cell tyrosine kinase-1 gene (FLT3) to 13q12→q13

Abstract

Access to Document

Fingerprint

Cite this