TY - JOUR
T1 - Localization of the human c-mos gene by in situ hybridization in two cases of acute nonlymphocytic leukemia type M2
AU - Rosendorff, J.
AU - Bowcock, A. M.
AU - Kuyl, J. M.
AU - Mendelow, B.
AU - Pinto, M. R.
AU - Bernstein, R.
PY - 1987/1
Y1 - 1987/1
N2 - The t(8;21)(q22.1;q22.3) is specific for the FAB-M2 subtype of acute nonlymphocytic leukemia (ANLL). The human c-mos protooncogene is located near the site of rearrangement on chromosome #8, at a position corresponding to band 8q22. The present in situ hybridization studies were performed in order to establish if c-mos is transposed from chromosome #8 to chromosome #21, in two cases of M2-ANLL showing the typical t(8;21). A statistical analysis of the results revealed that the c-mos oncogene was definitely not translocated from chromosome #8 to #21 in one of these patients, and was inconclusive in the other patient. The findings in the former patient suggest that either c-mos is not involved in the etiology of M2-ANLL or, alternatively, if c-mos is important in the pathogenesis of this disease, it must be activated by some mechanism other than transposition of this oncogene to an aberrant position.
AB - The t(8;21)(q22.1;q22.3) is specific for the FAB-M2 subtype of acute nonlymphocytic leukemia (ANLL). The human c-mos protooncogene is located near the site of rearrangement on chromosome #8, at a position corresponding to band 8q22. The present in situ hybridization studies were performed in order to establish if c-mos is transposed from chromosome #8 to chromosome #21, in two cases of M2-ANLL showing the typical t(8;21). A statistical analysis of the results revealed that the c-mos oncogene was definitely not translocated from chromosome #8 to #21 in one of these patients, and was inconclusive in the other patient. The findings in the former patient suggest that either c-mos is not involved in the etiology of M2-ANLL or, alternatively, if c-mos is important in the pathogenesis of this disease, it must be activated by some mechanism other than transposition of this oncogene to an aberrant position.
UR - http://www.scopus.com/inward/record.url?scp=0023205042&partnerID=8YFLogxK
U2 - 10.1016/0165-4608(87)90090-2
DO - 10.1016/0165-4608(87)90090-2
M3 - Article
C2 - 3466666
AN - SCOPUS:0023205042
SN - 0165-4608
VL - 24
SP - 137
EP - 141
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 1
ER -