TY - JOUR
T1 - Localization of cellular retinoid-binding proteins in human cervical intraepithelial neoplasia and invasive carcinoma
AU - Hillemanns, Peter
AU - Tannous-Khuri, Lamya
AU - Koulos, John P.
AU - Talmage, David
AU - Wright, Thomas C.
PY - 1992/10
Y1 - 1992/10
N2 - Cellular retinoic acid-binding protein (CRABP) and cellular retinal-binding protein (CRBP) were localized in biopsies of normal squamous epithelium, cervical intraepithelial neoplasia (CIN), and invasive squamous cell cancer of the cervix uteri by immunohistochemistry. In both the normal stratified squamous epithelium of the exocervix and low-grade CIN, CRABP I was present predominantly in the basal layer of the epithelium. The more superficial, differentiated cell layers lacked immunoreactive protein. In high grade CIN (CIN2-3), the distribution of CRABP I was altered. Immunoreactive CRABP I was detected in all layers of high-grade CIN. In squamous cell carcinoma of the cervix, CRABP I was detected in cells throughout the tumor but was minimal in cells demonstrating squamous differentiation. In contrast to CRABP I, CRBP was diffusely present throughout the cervical epithelium irrespective of the state of differentiation or the presence of disease.
AB - Cellular retinoic acid-binding protein (CRABP) and cellular retinal-binding protein (CRBP) were localized in biopsies of normal squamous epithelium, cervical intraepithelial neoplasia (CIN), and invasive squamous cell cancer of the cervix uteri by immunohistochemistry. In both the normal stratified squamous epithelium of the exocervix and low-grade CIN, CRABP I was present predominantly in the basal layer of the epithelium. The more superficial, differentiated cell layers lacked immunoreactive protein. In high grade CIN (CIN2-3), the distribution of CRABP I was altered. Immunoreactive CRABP I was detected in all layers of high-grade CIN. In squamous cell carcinoma of the cervix, CRABP I was detected in cells throughout the tumor but was minimal in cells demonstrating squamous differentiation. In contrast to CRABP I, CRBP was diffusely present throughout the cervical epithelium irrespective of the state of differentiation or the presence of disease.
UR - http://www.scopus.com/inward/record.url?scp=0026736812&partnerID=8YFLogxK
M3 - Article
C2 - 1329518
AN - SCOPUS:0026736812
SN - 0002-9440
VL - 141
SP - 973
EP - 980
JO - American Journal of Pathology
JF - American Journal of Pathology
IS - 4
ER -