Localization of a human heat-shock HSP 70 gene sequence to chromosome 6 and detection of two other loci by somatic-cell hybrid and restriction fragment length polymorphism analysis

Alison M. Goate; David N. Cooper; Christine Hall; Thomas K.C. Leung; Ellen Solomon; Louis Lim

doi:10.1007/BF00591072

Localization of a human heat-shock HSP 70 gene sequence to chromosome 6 and detection of two other loci by somatic-cell hybrid and restriction fragment length polymorphism analysis

Alison M. Goate
, David N. Cooper
, Christine Hall
, Thomas K.C. Leung
, Ellen Solomon
, Louis Lim

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Abstract

The human 70 kdalton heat-shock protein (HSP 70) is a member of a multigene family which is expressed in response to various physiological stresses including elevated temperatures. Using a cloned genomic HSP 70 DNA sequence we demonstrate by somatic cell hybrid and restriction fragment length polymorphism (RFLP) analyses that there are a minimum of three distinct HSP 70 loci in the human genome, one of which is located on chromosome 6.

Original language	English
Pages (from-to)	123-128
Number of pages	6
Journal	Human Genetics
Volume	75
Issue number	2
DOIs	https://doi.org/10.1007/BF00591072
State	Published - Feb 1987
Externally published	Yes

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10.1007/BF00591072

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title = "Localization of a human heat-shock HSP 70 gene sequence to chromosome 6 and detection of two other loci by somatic-cell hybrid and restriction fragment length polymorphism analysis",

abstract = "The human 70 kdalton heat-shock protein (HSP 70) is a member of a multigene family which is expressed in response to various physiological stresses including elevated temperatures. Using a cloned genomic HSP 70 DNA sequence we demonstrate by somatic cell hybrid and restriction fragment length polymorphism (RFLP) analyses that there are a minimum of three distinct HSP 70 loci in the human genome, one of which is located on chromosome 6.",

author = "Goate, \{Alison M.\} and Cooper, \{David N.\} and Christine Hall and Leung, \{Thomas K.C.\} and Ellen Solomon and Louis Lim",

year = "1987",

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AU - Goate, Alison M.

AU - Cooper, David N.

AU - Hall, Christine

AU - Leung, Thomas K.C.

AU - Solomon, Ellen

AU - Lim, Louis

PY - 1987/2

Y1 - 1987/2

N2 - The human 70 kdalton heat-shock protein (HSP 70) is a member of a multigene family which is expressed in response to various physiological stresses including elevated temperatures. Using a cloned genomic HSP 70 DNA sequence we demonstrate by somatic cell hybrid and restriction fragment length polymorphism (RFLP) analyses that there are a minimum of three distinct HSP 70 loci in the human genome, one of which is located on chromosome 6.

AB - The human 70 kdalton heat-shock protein (HSP 70) is a member of a multigene family which is expressed in response to various physiological stresses including elevated temperatures. Using a cloned genomic HSP 70 DNA sequence we demonstrate by somatic cell hybrid and restriction fragment length polymorphism (RFLP) analyses that there are a minimum of three distinct HSP 70 loci in the human genome, one of which is located on chromosome 6.

UR - https://www.scopus.com/pages/publications/0023139766

U2 - 10.1007/BF00591072

DO - 10.1007/BF00591072

M3 - Article

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AN - SCOPUS:0023139766

SN - 0340-6717

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SP - 123

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JO - Human Genetics

JF - Human Genetics

IS - 2

ER -

Localization of a human heat-shock HSP 70 gene sequence to chromosome 6 and detection of two other loci by somatic-cell hybrid and restriction fragment length polymorphism analysis

Abstract

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