Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13

Richard Wooster; Susan L. Neuhausen; Jonathan Mangion; Yvette Quirk; Deborah Ford; Nadine Collins; Kim Nguyen; Sheila Seal; Thao Tran; Diane Averill; Patty Fields; Gill Marshall; Steven Narod; Gilbert M. Lenoir; Henry Lynch; Jean Feunteun; Peter Devilee; Cees J. Cornelisse; Fred H. Menko; Peter A. Daly; Wilma Ormiston; Ross McManus; Carole Pye; Cathryn M. Lewis; Lisa A. Cannon-Albright; Julian Peto; Bruce A.J. Ponder; Mark H. Skolnick; Douglas F. Easton; David E. Goldgar; Michael R. Stratton

doi:10.1126/science.8091231

Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13

Richard Wooster
, Susan L. Neuhausen
, Jonathan Mangion
, Yvette Quirk
, Deborah Ford
, Nadine Collins
, Kim Nguyen
, Sheila Seal
, Thao Tran
, Diane Averill
, Patty Fields
, Gill Marshall
, Steven Narod
, Gilbert M. Lenoir
, Henry Lynch
, Jean Feunteun
, Peter Devilee
, Cees J. Cornelisse
, Fred H. Menko
, Peter A. Daly

Wilma Ormiston, Ross McManus, Carole Pye, Cathryn M. Lewis, Lisa A. Cannon-Albright, Julian Peto, Bruce A.J. Ponder, Mark H. Skolnick, Douglas F. Easton, David E. Goldgar, Michael R. Stratton

Research output: Contribution to journal › Article › peer-review

1758 Scopus citations

Abstract

A small proportion of breast cancer, in particular those cases arising at a young age, is due to the inheritance of dominant susceptibility genes conferring a high risk of the disease. A genomic linkage search was performed with 15 high-risk breast cancer families that were unlinked to the BRCA1 locus on chromosome 17q21. This analysis localized a second breast cancer susceptibility locus, BRCA2, to a 6-centimorgan interval on chromosome 13q12-13. Preliminary evidence suggests that BRCA2 confers a high risk of breast cancer but, unlike BRCA1, does not confer a substantially elevated risk of ovarian cancer.

Original language	English
Pages (from-to)	2088-2090
Number of pages	3
Journal	Science
Volume	265
Issue number	5181
DOIs	https://doi.org/10.1126/science.8091231
State	Published - 30 Sep 1994
Externally published	Yes

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10.1126/science.8091231

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Wooster, R., Neuhausen, S. L., Mangion, J., Quirk, Y., Ford, D., Collins, N., Nguyen, K., Seal, S., Tran, T., Averill, D., Fields, P., Marshall, G., Narod, S., Lenoir, G. M., Lynch, H., Feunteun, J., Devilee, P., Cornelisse, C. J., Menko, F. H., ... Stratton, M. R. (1994). Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13. Science, 265(5181), 2088-2090. https://doi.org/10.1126/science.8091231

@article{cb2c4acc30484bdbb54eb02ed9fb1d1b,

title = "Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13",

abstract = "A small proportion of breast cancer, in particular those cases arising at a young age, is due to the inheritance of dominant susceptibility genes conferring a high risk of the disease. A genomic linkage search was performed with 15 high-risk breast cancer families that were unlinked to the BRCA1 locus on chromosome 17q21. This analysis localized a second breast cancer susceptibility locus, BRCA2, to a 6-centimorgan interval on chromosome 13q12-13. Preliminary evidence suggests that BRCA2 confers a high risk of breast cancer but, unlike BRCA1, does not confer a substantially elevated risk of ovarian cancer.",

author = "Richard Wooster and Neuhausen, \{Susan L.\} and Jonathan Mangion and Yvette Quirk and Deborah Ford and Nadine Collins and Kim Nguyen and Sheila Seal and Thao Tran and Diane Averill and Patty Fields and Gill Marshall and Steven Narod and Lenoir, \{Gilbert M.\} and Henry Lynch and Jean Feunteun and Peter Devilee and Cornelisse, \{Cees J.\} and Menko, \{Fred H.\} and Daly, \{Peter A.\} and Wilma Ormiston and Ross McManus and Carole Pye and Lewis, \{Cathryn M.\} and Cannon-Albright, \{Lisa A.\} and Julian Peto and Ponder, \{Bruce A.J.\} and Skolnick, \{Mark H.\} and Easton, \{Douglas F.\} and Goldgar, \{David E.\} and Stratton, \{Michael R.\}",

year = "1994",

month = sep,

day = "30",

doi = "10.1126/science.8091231",

language = "English",

volume = "265",

pages = "2088--2090",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "5181",

}

Wooster, R, Neuhausen, SL, Mangion, J, Quirk, Y, Ford, D, Collins, N, Nguyen, K, Seal, S, Tran, T, Averill, D, Fields, P, Marshall, G, Narod, S, Lenoir, GM, Lynch, H, Feunteun, J, Devilee, P, Cornelisse, CJ, Menko, FH, Daly, PA, Ormiston, W, McManus, R, Pye, C, Lewis, CM, Cannon-Albright, LA, Peto, J, Ponder, BAJ, Skolnick, MH, Easton, DF, Goldgar, DE & Stratton, MR 1994, 'Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13', Science, vol. 265, no. 5181, pp. 2088-2090. https://doi.org/10.1126/science.8091231

TY - JOUR

T1 - Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13

AU - Wooster, Richard

AU - Neuhausen, Susan L.

AU - Mangion, Jonathan

AU - Quirk, Yvette

AU - Ford, Deborah

AU - Collins, Nadine

AU - Nguyen, Kim

AU - Seal, Sheila

AU - Tran, Thao

AU - Averill, Diane

AU - Fields, Patty

AU - Marshall, Gill

AU - Narod, Steven

AU - Lenoir, Gilbert M.

AU - Lynch, Henry

AU - Feunteun, Jean

AU - Devilee, Peter

AU - Cornelisse, Cees J.

AU - Menko, Fred H.

AU - Daly, Peter A.

AU - Ormiston, Wilma

AU - McManus, Ross

AU - Pye, Carole

AU - Lewis, Cathryn M.

AU - Cannon-Albright, Lisa A.

AU - Peto, Julian

AU - Ponder, Bruce A.J.

AU - Skolnick, Mark H.

AU - Easton, Douglas F.

AU - Goldgar, David E.

AU - Stratton, Michael R.

PY - 1994/9/30

Y1 - 1994/9/30

N2 - A small proportion of breast cancer, in particular those cases arising at a young age, is due to the inheritance of dominant susceptibility genes conferring a high risk of the disease. A genomic linkage search was performed with 15 high-risk breast cancer families that were unlinked to the BRCA1 locus on chromosome 17q21. This analysis localized a second breast cancer susceptibility locus, BRCA2, to a 6-centimorgan interval on chromosome 13q12-13. Preliminary evidence suggests that BRCA2 confers a high risk of breast cancer but, unlike BRCA1, does not confer a substantially elevated risk of ovarian cancer.

AB - A small proportion of breast cancer, in particular those cases arising at a young age, is due to the inheritance of dominant susceptibility genes conferring a high risk of the disease. A genomic linkage search was performed with 15 high-risk breast cancer families that were unlinked to the BRCA1 locus on chromosome 17q21. This analysis localized a second breast cancer susceptibility locus, BRCA2, to a 6-centimorgan interval on chromosome 13q12-13. Preliminary evidence suggests that BRCA2 confers a high risk of breast cancer but, unlike BRCA1, does not confer a substantially elevated risk of ovarian cancer.

UR - https://www.scopus.com/pages/publications/0028006563

U2 - 10.1126/science.8091231

DO - 10.1126/science.8091231

M3 - Article

C2 - 8091231

AN - SCOPUS:0028006563

SN - 0036-8075

VL - 265

SP - 2088

EP - 2090

JO - Science

JF - Science

IS - 5181

ER -

Localization of a breast cancer susceptibility gene, BRCA2, to chromosome 13q12-13

Abstract

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