Local hyperthermia induces apoptosis of keratinocytes in both normal skin and condyloma acuminata via different pathways

Xiaoqin Wang, Xing Hua Gao, Xiaodong Li, Yuxiao Hong, Ruiqun Qi, Hong Duo Chen, Li Zhang, Huachen Wei

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Local hyperthermia has been successfully used in the treatment of viral warts. However, the mechanism of action of hyperthermia has largely remained unclear. In this study we evaluated the effect of local hyperthermia on the induction of apoptosis in human keratinocytes, and expression of apoptosis-related genes in both condyloma acuminata (CA) and normal skin. The study showed that higher hyperthermia increased the number of apoptotic keratinocytes in CA and normal skin. The temperaturedependent increased expression of Fas and Bax were observed in both CA and normal skin. In contrast, the expression of Bcl-2 in CA was decreased at both transcriptional and translational levels. Furthermore, the transcriptional expression of DR4 and DR5 were increased in a temperature-dependent manner in CA, but not in normal skin. These results suggest that different mechanisms of action might be involved in hyperthermia induced apoptosis in CA and normal skin.

Original languageEnglish
Pages (from-to)721-728
Number of pages8
JournalApoptosis : an international journal on programmed cell death
Volume14
Issue number5
DOIs
StatePublished - May 2009

Keywords

  • Apoptosis
  • Condyloma acuminata
  • Hyperthermia
  • Skin

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