Local flicker stimulation evokes local retinal blood velocity changes

Zhangyi Zhong; Gang Huang; Toco Yuen Ping Chui; Benno L. Petrig; Stephen A. Burns

doi:10.1167/12.6.3

Local flicker stimulation evokes local retinal blood velocity changes

Zhangyi Zhong, Gang Huang, Toco Yuen Ping Chui, Benno L. Petrig, Stephen A. Burns

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

We investigated the effect of localized visual stimulation on human retinal blood velocity using an adaptive optics scanning laser ophthalmoscope (AOSLO). To measure the blood velocity response, the AOSLO scanning raster was moved over thetarget arteries and red blood cell velocity was measured. Localized visual stimuli were delivered by projecting flicker patterns inside or outside the target artery's downstream region. The blood velocity increased in the presence of a flicker stimulus in the downstream region but not when outside the downstream region. The blood velocity increased more with larger area of stimulation. This increase was significant even when the stimulus was smaller than 600 μm × 600 μm. These findings suggest that when the retina regulates its blood flow to metabolic demands, it regulates blood velocity in the vascularsystem selectively, according to activity of neurons within its field of influence.

Original language	English
Article number	3
Journal	Journal of Vision
Volume	12
Issue number	6
DOIs	https://doi.org/10.1167/12.6.3
State	Published - 2012
Externally published	Yes

Keywords

Functional imaging
Ganglion cells
Retina

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title = "Local flicker stimulation evokes local retinal blood velocity changes",

abstract = "We investigated the effect of localized visual stimulation on human retinal blood velocity using an adaptive optics scanning laser ophthalmoscope (AOSLO). To measure the blood velocity response, the AOSLO scanning raster was moved over thetarget arteries and red blood cell velocity was measured. Localized visual stimuli were delivered by projecting flicker patterns inside or outside the target artery's downstream region. The blood velocity increased in the presence of a flicker stimulus in the downstream region but not when outside the downstream region. The blood velocity increased more with larger area of stimulation. This increase was significant even when the stimulus was smaller than 600 μm × 600 μm. These findings suggest that when the retina regulates its blood flow to metabolic demands, it regulates blood velocity in the vascularsystem selectively, according to activity of neurons within its field of influence.",

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author = "Zhangyi Zhong and Gang Huang and Chui, {Toco Yuen Ping} and Petrig, {Benno L.} and Burns, {Stephen A.}",

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AU - Zhong, Zhangyi

AU - Huang, Gang

AU - Chui, Toco Yuen Ping

AU - Petrig, Benno L.

AU - Burns, Stephen A.

PY - 2012

Y1 - 2012

N2 - We investigated the effect of localized visual stimulation on human retinal blood velocity using an adaptive optics scanning laser ophthalmoscope (AOSLO). To measure the blood velocity response, the AOSLO scanning raster was moved over thetarget arteries and red blood cell velocity was measured. Localized visual stimuli were delivered by projecting flicker patterns inside or outside the target artery's downstream region. The blood velocity increased in the presence of a flicker stimulus in the downstream region but not when outside the downstream region. The blood velocity increased more with larger area of stimulation. This increase was significant even when the stimulus was smaller than 600 μm × 600 μm. These findings suggest that when the retina regulates its blood flow to metabolic demands, it regulates blood velocity in the vascularsystem selectively, according to activity of neurons within its field of influence.

AB - We investigated the effect of localized visual stimulation on human retinal blood velocity using an adaptive optics scanning laser ophthalmoscope (AOSLO). To measure the blood velocity response, the AOSLO scanning raster was moved over thetarget arteries and red blood cell velocity was measured. Localized visual stimuli were delivered by projecting flicker patterns inside or outside the target artery's downstream region. The blood velocity increased in the presence of a flicker stimulus in the downstream region but not when outside the downstream region. The blood velocity increased more with larger area of stimulation. This increase was significant even when the stimulus was smaller than 600 μm × 600 μm. These findings suggest that when the retina regulates its blood flow to metabolic demands, it regulates blood velocity in the vascularsystem selectively, according to activity of neurons within its field of influence.

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Local flicker stimulation evokes local retinal blood velocity changes

Abstract

Keywords

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