Local excision versus radical resection in patients with rectal neuroendocrine tumours: a propensity score match analysis

Beiqun Zhao, Hannah M. Hollandsworth, Nicole E. Lopez, Lisa A. Parry, Benjamin Abbadessa, Bard C. Cosman, Sonia L. Ramamoorthy, Samuel Eisenstein

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Background: The rectum is a common site for neuroendocrine tumours of the gastrointestinal tract. Diagnosis of these tumours has been increasing in recent years, highlighting the need to better define treatment options for patients with rectal neuroendocrine tumours (rNETs). Methods: We performed a retrospective analysis using the National Cancer Database (2004–2014) to compare overall survival (OS) between local excision (LE) and radical resection (RR). To minimize bias, we performed three propensity score-matched comparisons stratified by tumour size: <10 mm, 10–20 mm, >20 mm. We compared OS by Kaplan–Meier analysis. We also examined margin status and postoperative outcomes for each comparison. Results: A total of 12 996 patients underwent surgical treatment for rNET. There was no significant difference in probability of 10-year OS between LE and RR for patients with tumours <10 mm (88.6% versus 83.8%, P = 0.631, respectively) and tumours 10-20 mm (69.5% versus 69.3%, P = 0.226, respectively). In patients with tumours >20 mm, probability of 10-year OS was significantly longer in the LE group (76.5% versus 37.0%, P < 0.001). For all tumour sizes <10 mm and >20 mm, RR had significantly higher rates of 30-day readmission and negative margins. In subset analysis, there was no difference in OS for patients with positive margins after LE versus negative margins after RR for all tumour size groups. Conclusions: Our findings suggest that LE is a reasonable treatment option in patients with rNETs, especially for patients with high perioperative risk. Limitations to this study include its retrospective nature and inability to analyse surgeon decision-making.

Original languageEnglish
Pages (from-to)E154-E162
JournalANZ Journal of Surgery
Volume90
Issue number12
DOIs
StatePublished - Dec 2020
Externally publishedYes

Keywords

  • National Cancer Database
  • carcinoid
  • propensity score matching
  • rectal neuroendocrine tumour

Fingerprint

Dive into the research topics of 'Local excision versus radical resection in patients with rectal neuroendocrine tumours: a propensity score match analysis'. Together they form a unique fingerprint.

Cite this