Local Efficacy of Glutamate Uptake Decreases with Synapse Size

Michel K. Herde, Kirsten Bohmbach, Cátia Domingos, Natascha Vana, Joanna A. Komorowska-Müller, Stefan Passlick, Inna Schwarz, Colin J. Jackson, Dirk Dietrich, Martin K. Schwarz, Christian Henneberger

Research output: Contribution to journalArticlepeer-review

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Abstract

Herde et al. demonstrate a dependence of the local efficacy of glutamate uptake at glutamatergic synapses on spine size. As predicted by the relative astrocytic coverage of spines, extracellular glutamate transients and Ca2+ entry through glutamate receptors are less strongly controlled by glutamate uptake at large than at small spines.

Original languageEnglish
Article number108182
JournalCell Reports
Volume32
Issue number12
DOIs
StatePublished - 22 Sep 2020
Externally publishedYes

Keywords

  • astrocyte morphology
  • astrocytes
  • expansion microscopy
  • glutamate uptake
  • hippocampus
  • multiphoton imaging
  • spine morphology

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