Lobular carcinoma in situ as a nonpalpable breast lesion: Mammographic features and pathologic correlation

George Hermann, Rhona Keller, Paul Tartter, Ira Bleiweiss, Jean Marc Cohen, Jack G. Rabinowitz

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


The mammographic findings in 35 cases of histologically diagnosed lobular carcinoma in situ (LCIS) were retrospectively reviewed and correlated with the histopathology. All of the lesions were nonpalpable, and needle localization preceded their surgical removal. Radiologic features including size, number, and pattern of calcifications and the presence or absence of mass were evaluated. In 17 cases, LCIS was the only evidence of neoplasia. In eight of these cases, radiographically detected calcifications were histologically found in the LCIS. Although five of these eight cases also showed calcifications in nonneoplastic breast, in the other three cases the calcifications were histologically present only in LCIS. In one case, calcifications were found on histopathology in LCIS but not seen on x-ray films. In the remaining eight cases, calcifications were present in fibrocystic changes but not in LCIS. In no case did LCIS correspond to a mass lesion. In 18 of the 35 cases, LCIS was associated with duct carcinoma in situ (DCIS) and/or infiltrating carcinoma. In 14 of these cases, calcifications were the presenting feature, whereas in four cases a mass was noted. Seven of the lesions showed calcifications in both DCIS and LCIS. The pattern of calcifications in LCIS with or without associated benign lesions showed illdefined, low-density, round dots with lucent centers. In contrast, in the group including infiltrating carcinoma and/or DCIS, the pattern consisted of short, linear, branching, indistinct calcifications present in the carcinoma. We conclude that calcifications associated with LCIS are not uncommon (16 of 35 cases) and that LCIS may be suggested radiographically by indistinct dots with lucent centers.

Original languageEnglish
Pages (from-to)269-276
Number of pages8
JournalBreast Disease
Issue number4
StatePublished - Oct 1993
Externally publishedYes


  • Breast calcification
  • breast calcification in LCIS


Dive into the research topics of 'Lobular carcinoma in situ as a nonpalpable breast lesion: Mammographic features and pathologic correlation'. Together they form a unique fingerprint.

Cite this