TY - JOUR
T1 - Liver transglutaminase activity under various experimental conditions
AU - Wajda, Isabel
AU - Acs, George
AU - Clarke, Donald D.
AU - Waelsch, Heinrich
N1 - Funding Information:
* This work was supported in part by grants from the National Institute of Neurological Diseases and Blindness (Grant B-226) and from the Ford Foundation; and by a contract between the OtTice of Naval Research and the Psychiatric Institute, New York, N.Y. Fart of this work was presented by H. Waelsch in a symposium on “Les Monoamines et le Systeme Nerveux Central,” Clinique Bel-Air, Geneve, September, 1961. Preliminary reports were published.lp 2 t Present address: Institute for Muscle Disease, Inc., 515 East 71st Street, New York, N.Y.
PY - 1963/3
Y1 - 1963/3
N2 - Bacterial endotoxins and Haemophilus pertussis vaccine were found to increase the activity of liver transglutaminase in mice, rats, and guinea pigs. Enzyme activity increased also in the spleen of the injected mice, whereas no significant changes were found in the thymus, the lung, and the brain. The enzyme activity in adrenalectomized mice increased in the liver. Pretreatment of the animal with cortisone antagonized the rise in liver transglutaminase after endotoxin administration. The enzyme obtained from the liver of endotoxin-treated mice has the characteristics of transglutaminase obtained from the livers of normal mice. Mice and rats have a low enzyme activity in the liver and show a considerable increase upon administration of H. pertussis vaccine and purified endotoxins. Guinea pig liver, which is the richest source of transglutaminase so far found, shows a significant increase only upon the administration of high doses of endotoxins but not of pertussis vaccine.
AB - Bacterial endotoxins and Haemophilus pertussis vaccine were found to increase the activity of liver transglutaminase in mice, rats, and guinea pigs. Enzyme activity increased also in the spleen of the injected mice, whereas no significant changes were found in the thymus, the lung, and the brain. The enzyme activity in adrenalectomized mice increased in the liver. Pretreatment of the animal with cortisone antagonized the rise in liver transglutaminase after endotoxin administration. The enzyme obtained from the liver of endotoxin-treated mice has the characteristics of transglutaminase obtained from the livers of normal mice. Mice and rats have a low enzyme activity in the liver and show a considerable increase upon administration of H. pertussis vaccine and purified endotoxins. Guinea pig liver, which is the richest source of transglutaminase so far found, shows a significant increase only upon the administration of high doses of endotoxins but not of pertussis vaccine.
UR - https://www.scopus.com/pages/publications/2042434485
U2 - 10.1016/0006-2952(63)90147-3
DO - 10.1016/0006-2952(63)90147-3
M3 - Article
C2 - 13998352
AN - SCOPUS:2042434485
SN - 0006-2952
VL - 12
SP - 241
EP - 250
JO - Biochemical Pharmacology
JF - Biochemical Pharmacology
IS - 3
ER -