Liver Disease in Human Immunodeficiency Virus Infection

Katerina G. Oikonomou, Eugenia Tsai, Dost Sarpel, Douglas T. Dieterich

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Liver disease in human immunodeficiency virus (HIV) remains a main cause of morbidity and mortality. Liver-related morbidity and mortality can be caused by multiple etiologic factors, including opportunistic infections, direct and indirect effects of antiretrovirals, direct and indirect effects of HIV, and viral hepatitides. These factors present with varied liver pathophysiologic mechanisms that lead to abnormalities in liver enzymes and synthetic function test, followed by distinct clinical presentations. This article elucidates the direct effects on HIV in the liver and explores the diagnostic and management challenges in patients with HIV in the era of highly active antiretroviral treatment.

Original languageEnglish
Pages (from-to)309-329
Number of pages21
JournalClinics in Liver Disease
Issue number2
StatePublished - May 2019


  • ART
  • HIV
  • Hepatitis
  • Liver


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