Lithium carbonate as a treatment for paliperidone extended-release-induced leukopenia and neutropenia in a patient with schizoaffective disorder; a case report

Hiroki Matsuura; Sohei Kimoto; Izumi Harada; Satoshi Naemura; Kazuhiko Yamamuro; Toshifumi Kishimoto

doi:10.1186/s12888-016-0874-x

Lithium carbonate as a treatment for paliperidone extended-release-induced leukopenia and neutropenia in a patient with schizoaffective disorder; a case report

Hiroki Matsuura, Sohei Kimoto, Izumi Harada, Satoshi Naemura, Kazuhiko Yamamuro, Toshifumi Kishimoto

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Background: Antipsychotic drug treatment can potentially lead to adverse events such as leukopenia and neutropenia. Although these events are rare, they represent serious and life-threatening hematological side effects. Case presentation: We present a case study of a patient with schizoaffective disorder in a 50-year-old woman. We report a case of paliperidone extended-release (ER)-induced leukopenia and neutropenia in a female patient with schizoaffective disorder. Initiating lithium carbonate treatment and decreasing the dose of valproic acid improved the observed leukopenia and neutropenia. This treatment did not influence psychotic symptoms. Conclusion: The combination of paliperidone ER and valproic acid induces increased paliperidone ER plasma levels. Lithium carbonate was successfully used to treat paliperidone ER-induced leukopenia and neutropenia.

Original language	English
Article number	161
Journal	BMC Psychiatry
Volume	16
Issue number	1
DOIs	https://doi.org/10.1186/s12888-016-0874-x
State	Published - 26 May 2016
Externally published	Yes

Keywords

Leukopenia
Lithium carbonate
Neutropenia
Paliperidone extended-release
Schizoaffective disorder
Schizophrenia
Valproic acid

Access to Document

10.1186/s12888-016-0874-x

Cite this

@article{38a7b922c42f4b0192e7ffbbca8825c7,

title = "Lithium carbonate as a treatment for paliperidone extended-release-induced leukopenia and neutropenia in a patient with schizoaffective disorder; a case report",

abstract = "Background: Antipsychotic drug treatment can potentially lead to adverse events such as leukopenia and neutropenia. Although these events are rare, they represent serious and life-threatening hematological side effects. Case presentation: We present a case study of a patient with schizoaffective disorder in a 50-year-old woman. We report a case of paliperidone extended-release (ER)-induced leukopenia and neutropenia in a female patient with schizoaffective disorder. Initiating lithium carbonate treatment and decreasing the dose of valproic acid improved the observed leukopenia and neutropenia. This treatment did not influence psychotic symptoms. Conclusion: The combination of paliperidone ER and valproic acid induces increased paliperidone ER plasma levels. Lithium carbonate was successfully used to treat paliperidone ER-induced leukopenia and neutropenia.",

keywords = "Leukopenia, Lithium carbonate, Neutropenia, Paliperidone extended-release, Schizoaffective disorder, Schizophrenia, Valproic acid",

author = "Hiroki Matsuura and Sohei Kimoto and Izumi Harada and Satoshi Naemura and Kazuhiko Yamamuro and Toshifumi Kishimoto",

note = "Publisher Copyright: {\textcopyright} 2016 Matsuura et al.",

year = "2016",

month = may,

day = "26",

doi = "10.1186/s12888-016-0874-x",

language = "English",

volume = "16",

journal = "BMC Psychiatry",

issn = "1471-244X",

publisher = "BioMed Central Ltd.",

number = "1",

}

TY - JOUR

T1 - Lithium carbonate as a treatment for paliperidone extended-release-induced leukopenia and neutropenia in a patient with schizoaffective disorder; a case report

AU - Matsuura, Hiroki

AU - Kimoto, Sohei

AU - Harada, Izumi

AU - Naemura, Satoshi

AU - Yamamuro, Kazuhiko

AU - Kishimoto, Toshifumi

PY - 2016/5/26

Y1 - 2016/5/26

N2 - Background: Antipsychotic drug treatment can potentially lead to adverse events such as leukopenia and neutropenia. Although these events are rare, they represent serious and life-threatening hematological side effects. Case presentation: We present a case study of a patient with schizoaffective disorder in a 50-year-old woman. We report a case of paliperidone extended-release (ER)-induced leukopenia and neutropenia in a female patient with schizoaffective disorder. Initiating lithium carbonate treatment and decreasing the dose of valproic acid improved the observed leukopenia and neutropenia. This treatment did not influence psychotic symptoms. Conclusion: The combination of paliperidone ER and valproic acid induces increased paliperidone ER plasma levels. Lithium carbonate was successfully used to treat paliperidone ER-induced leukopenia and neutropenia.

AB - Background: Antipsychotic drug treatment can potentially lead to adverse events such as leukopenia and neutropenia. Although these events are rare, they represent serious and life-threatening hematological side effects. Case presentation: We present a case study of a patient with schizoaffective disorder in a 50-year-old woman. We report a case of paliperidone extended-release (ER)-induced leukopenia and neutropenia in a female patient with schizoaffective disorder. Initiating lithium carbonate treatment and decreasing the dose of valproic acid improved the observed leukopenia and neutropenia. This treatment did not influence psychotic symptoms. Conclusion: The combination of paliperidone ER and valproic acid induces increased paliperidone ER plasma levels. Lithium carbonate was successfully used to treat paliperidone ER-induced leukopenia and neutropenia.

KW - Leukopenia

KW - Lithium carbonate

KW - Neutropenia

KW - Paliperidone extended-release

KW - Schizoaffective disorder

KW - Schizophrenia

KW - Valproic acid

UR - http://www.scopus.com/inward/record.url?scp=84970045838&partnerID=8YFLogxK

U2 - 10.1186/s12888-016-0874-x

DO - 10.1186/s12888-016-0874-x

M3 - Article

C2 - 27229149

AN - SCOPUS:84970045838

SN - 1471-244X

VL - 16

JO - BMC Psychiatry

JF - BMC Psychiatry

IS - 1

M1 - 161

ER -

Lithium carbonate as a treatment for paliperidone extended-release-induced leukopenia and neutropenia in a patient with schizoaffective disorder; a case report

Abstract

Keywords

Access to Document

Fingerprint

Cite this