TY - JOUR
T1 - Literature Review and Meta-Analysis of Topical Carbonic Anhydrase Inhibitors and Ocular Blood Flow
AU - Siesky, Brent
AU - Harris, Alon
AU - Brizendine, Edward
AU - Marques, Clarice
AU - Loh, Jennifer
AU - Mackey, Joseph
AU - Overton, Jennifer
AU - Netland, Peter
N1 - Funding Information:
This review was supported in part by an unrestricted grant from Research to Prevent Blindness, New York, NY, and a grant from Merck pharmaceuticals. The authors reported no proprietary or commercial interest in any product mentioned or concept discussed in this article. The authors acknowledge the assistance of Ann Hammer, Department of Ophthalmology Librarian, Indiana University School of Medicine, and Lynne McCranor, clinical study coordinator, Department of Ophthalmology, Indiana University School of Medicine.
PY - 2009/1
Y1 - 2009/1
N2 - The purpose of this literature review and meta-analysis was to determine what, if any, effects topical carbonic anhydrase inhibitors have on ocular hemodynamics in humans. A literature review and meta-analysis was conducted to investigate the effects of topical carbonic anhydrase inhibitors on ocular blood flow. Thirty-five articles were evaluated according to the inclusion criteria with 13 manuscripts meeting requirements for statistical analysis. Each study's effect size, defined as the change in blood flow measures after treatment with topical carbonic anhydrase inhibitors, was estimated using the weighted mean difference. Based on this meta-analysis, we conclude that topical carbonic anhydrase inhibitors increase ocular blood flow velocities in the retinal circulation, central retinal and short posterior ciliary arteries, but not in the ophthalmic artery.
AB - The purpose of this literature review and meta-analysis was to determine what, if any, effects topical carbonic anhydrase inhibitors have on ocular hemodynamics in humans. A literature review and meta-analysis was conducted to investigate the effects of topical carbonic anhydrase inhibitors on ocular blood flow. Thirty-five articles were evaluated according to the inclusion criteria with 13 manuscripts meeting requirements for statistical analysis. Each study's effect size, defined as the change in blood flow measures after treatment with topical carbonic anhydrase inhibitors, was estimated using the weighted mean difference. Based on this meta-analysis, we conclude that topical carbonic anhydrase inhibitors increase ocular blood flow velocities in the retinal circulation, central retinal and short posterior ciliary arteries, but not in the ophthalmic artery.
KW - carbonic anhydrase inhibitor
KW - color Doppler imaging
KW - glaucoma
KW - ocular blood flow
KW - scanning laser ophthalmoscopy
UR - http://www.scopus.com/inward/record.url?scp=58449130391&partnerID=8YFLogxK
U2 - 10.1016/j.survophthal.2008.06.002
DO - 10.1016/j.survophthal.2008.06.002
M3 - Review article
C2 - 19171209
AN - SCOPUS:58449130391
SN - 0039-6257
VL - 54
SP - 33
EP - 46
JO - Survey of Ophthalmology
JF - Survey of Ophthalmology
IS - 1
ER -