Lipoproteins as Biomarkers and Therapeutic Targets in the Setting of Acute Coronary Syndrome

Robert S. Rosenson, H. Bryan Brewer, Daniel J. Rader

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

The period following an acute coronary syndrome (ACS) represents a critical time frame with a high risk for recurrent events and death. The pathogenesis of this increase in clinical cardiovascular disease events after ACS is complex, with molecular mechanisms including increased thrombosis and inflammation. Dyslipoproteinemia is common in patients with ACS and predictive of recurrent cardiovascular disease events after presentation with an ACS event. Although randomized clinical trials have provided fairly convincing evidence that high-dose statins reduce the risk of recurrent cardiovascular events after ACS, there remain questions about how aggressively to reduce low-density lipoprotein cholesterol levels in ACS. Furthermore, no other lipid-related interventions have yet been proven to be effective in reducing major cardiovascular events after ACS. Here, we review the relationship of lipoproteins as biomarkers to cardiovascular risk after ACS, the evidence for lipid-targeted interventions, and the potential for novel therapeutic approaches in this arena.

Original languageEnglish
Pages (from-to)1880-1889
Number of pages10
JournalCirculation Research
Volume114
Issue number12
DOIs
StatePublished - 19 Jun 2014

Keywords

  • Cholesterol
  • Coronary artery disease
  • Lipids

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