Lipoprotein-X and Lipoprotein-Z Induced Hyperviscosity Syndrome in the Setting of Cholestatic Liver Failure

Ori Waksman; Daniel J. Cho; Hyoung Sup Kim; James D. Otvos; Robert S. Rosenson

doi:10.1016/j.jaccas.2022.09.001

Lipoprotein-X and Lipoprotein-Z Induced Hyperviscosity Syndrome in the Setting of Cholestatic Liver Failure

Ori Waksman
, Daniel J. Cho
, Hyoung Sup Kim
, James D. Otvos
, Robert S. Rosenson

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

We describe a case referred for worsening hypercholesterolemia in the setting of atorvastatin and fenofibrate-induced liver injury. The patient reported neurological complaints attributed to hyperviscosity syndrome (induced by lipoprotein-X and lipoprotein-Z). Hepatic recovery was associated with reduction of whole blood viscosity and amelioration of neurological symptoms. (Level of Difficulty: Advanced.)

Original language	English
Pages (from-to)	1348-1352
Number of pages	5
Journal	JACC: Case Reports
Volume	4
Issue number	20
DOIs	https://doi.org/10.1016/j.jaccas.2022.09.001
State	Published - 19 Oct 2022

Keywords

cholestasis
cholesterol
dyslipidemia
hyperviscosity syndrome
lipids
lipoprotein
lipoprotein-X
lipoprotein-Z

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10.1016/j.jaccas.2022.09.001

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title = "Lipoprotein-X and Lipoprotein-Z Induced Hyperviscosity Syndrome in the Setting of Cholestatic Liver Failure",

abstract = "We describe a case referred for worsening hypercholesterolemia in the setting of atorvastatin and fenofibrate-induced liver injury. The patient reported neurological complaints attributed to hyperviscosity syndrome (induced by lipoprotein-X and lipoprotein-Z). Hepatic recovery was associated with reduction of whole blood viscosity and amelioration of neurological symptoms. (Level of Difficulty: Advanced.)",

keywords = "cholestasis, cholesterol, dyslipidemia, hyperviscosity syndrome, lipids, lipoprotein, lipoprotein-X, lipoprotein-Z",

author = "Ori Waksman and Cho, \{Daniel J.\} and Kim, \{Hyoung Sup\} and Otvos, \{James D.\} and Rosenson, \{Robert S.\}",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors",

year = "2022",

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doi = "10.1016/j.jaccas.2022.09.001",

language = "English",

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T1 - Lipoprotein-X and Lipoprotein-Z Induced Hyperviscosity Syndrome in the Setting of Cholestatic Liver Failure

AU - Waksman, Ori

AU - Cho, Daniel J.

AU - Kim, Hyoung Sup

AU - Otvos, James D.

AU - Rosenson, Robert S.

PY - 2022/10/19

Y1 - 2022/10/19

N2 - We describe a case referred for worsening hypercholesterolemia in the setting of atorvastatin and fenofibrate-induced liver injury. The patient reported neurological complaints attributed to hyperviscosity syndrome (induced by lipoprotein-X and lipoprotein-Z). Hepatic recovery was associated with reduction of whole blood viscosity and amelioration of neurological symptoms. (Level of Difficulty: Advanced.)

AB - We describe a case referred for worsening hypercholesterolemia in the setting of atorvastatin and fenofibrate-induced liver injury. The patient reported neurological complaints attributed to hyperviscosity syndrome (induced by lipoprotein-X and lipoprotein-Z). Hepatic recovery was associated with reduction of whole blood viscosity and amelioration of neurological symptoms. (Level of Difficulty: Advanced.)

KW - cholestasis

KW - cholesterol

KW - dyslipidemia

KW - hyperviscosity syndrome

KW - lipids

KW - lipoprotein

KW - lipoprotein-X

KW - lipoprotein-Z

UR - https://www.scopus.com/pages/publications/85139273789

U2 - 10.1016/j.jaccas.2022.09.001

DO - 10.1016/j.jaccas.2022.09.001

M3 - Article

AN - SCOPUS:85139273789

SN - 2666-0849

VL - 4

SP - 1348

EP - 1352

JO - JACC: Case Reports

JF - JACC: Case Reports

IS - 20

ER -

Lipoprotein-X and Lipoprotein-Z Induced Hyperviscosity Syndrome in the Setting of Cholestatic Liver Failure

Abstract

Keywords

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