Lipogenic metabolism: A viable target for prostate cancer treatment?

Mengmeng Liang, David J. Mulholland

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Cancer cells often depend on altered metabolism compared with their normal counterparts. [1],[2],[3],[4]As observed in 1924 by Otto Warburg, cancer cells show preferential glucose consumption by way of aerobic glycolysis while normal cells generally assume mitochondrial oxidative phosphorylation. [4]Another metabolic hallmark of carcinogenesis is altered lipid metabolism, whereby cancer cells may adopt enhanced de novo lipid production (lipogenesis). [1],[2],[3]Enhanced lipid metabolism is also observed in individuals with metabolic syndromes potentially a consequence of increasing popularity of the Standard American Diet, composed of high levels of saturated fats and carbohydrates. [5]A growing body of epidemiological data indicates a positive correlation between the occurrence of metabolic syndromes, such as cardiovascular disease, obesity, type-2 diabetes and associated hyperinsulemia, with the aggressiveness of cancer. [6],[7],[8],[9]Remarkably, it is estimated that for every 1% reduction in saturated fats, replaced by polyunsaturated, there would be a 2%-3% reduction in cardiovascular disease. [10]Thus, it is conceivable that an equally remarkable attenuation in cancer progression might be achieved with such a reduction in lipid accumulation.

Original languageEnglish
Pages (from-to)661-663
Number of pages3
JournalAsian Journal of Andrology
Issue number5
StatePublished - 1 Sep 2014


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