Nuclear lipid metabolism and metabolites play important roles in the regulation of lipid-lipid, lipid-gene, lipid-chromatin, lipid-membrane, and lipid-protein interactions to maintain the nuclear microenvironment, three-dimensional chromatin architecture, gene expression and transcription, and biological function. This editorial highlights the value of lipid-gene in the identification and development of biomarkers and targets and emphasises the significance of interregulation between lipids and genes in the innovation and application of precise therapies for patients. Regulatory functions of nuclear lipid dynamics and biophysics modify transcriptomic expression, and modification (lipotranscriptome) can be a new approach for discovery and development of disease-specific diagnoses and therapies, although there are several challenges to be overcome. A better understanding of how lipid-based changes in nuclear functions and transcriptomic profiles modify clinical phenomes will provide new insights to understand the molecular mechanisms of diseases and to develop spatiotemporal molecular medicine diagnostics and therapeutics.

Original languageEnglish
Article numbere67
JournalClinical and Translational Discovery
Issue number2
StatePublished - Jun 2022


  • disease
  • genes
  • lipid metabolism
  • lipids
  • lipotranscriptome
  • nuclear lipid droplets


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