Lipid mediators in neutrophil biology: Inflammation, resolution and beyond

Anita Ghodsi, Andres Hidalgo, Stephania Libreros

Research output: Contribution to journalReview articlepeer-review

Abstract

Purpose of reviewAcute inflammation is the body's first defense in response to pathogens or injury. Failure to efficiently resolve the inflammatory insult can severely affect tissue homeostasis, leading to chronic inflammation. Neutrophils play a pivotal role in eradicating infectious pathogens, orchestrating the initiation and resolution of acute inflammation, and maintaining physiological functions. The resolution of inflammation is a highly orchestrated biochemical process, partially modulated by a novel class of endogenous lipid mediators known as specialized pro-resolving mediators (SPMs). SPMs mediate their potent bioactions via activating specific cell-surface G protein-coupled receptors (GPCR).Recent findingsThis review focuses on recent advances in understanding the multifaceted functions of SPMs, detailing their roles in expediting neutrophil apoptosis, promoting clearance by macrophages, regulating their excessive infiltration at inflammation sites, orchestrating bone marrow deployment, also enhances neutrophil phagocytosis and tissue repair mechanisms under both physiological and pathological conditions. We also focus on the novel role of SPMs in regulating bone marrow neutrophil functions, differentiation, and highlight open questions about SPMs' functions in neutrophil heterogeneity.SummarySPMs play a pivotal role in mitigating excessive neutrophil infiltration and hyperactivity within pathological milieus, notably in conditions such as sepsis, cardiovascular disease, ischemic events, and cancer. This significant function highlights SPMs as promising therapeutic agents in the management of both acute and chronic inflammatory disorders.

Original languageEnglish
Pages (from-to)175-192
Number of pages18
JournalCurrent Opinion in Hematology
Volume31
Issue number4
DOIs
StatePublished - 1 Jul 2024
Externally publishedYes

Keywords

  • Resolvins
  • bone marrow
  • heterogeneity
  • specialized pro-resolving mediators

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