Lipid management in patients presenting with acute coronary syndromes: A review

Bimmer E. Claessen, Paul Guedeney, C. Michael Gibson, Dominick J. Angiolillo, Davide Cao, Norman Lepor, Roxana Mehran

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations


Despite many improvements in its prevention and management, acute coronary syndrome (ACS) remains a major cause of morbidity and mortality in the developed world. Lipid management is an important part of secondary prevention after ACS, but many patients currently remain undertreated and do not attain guideline-recommended levels of low-density lipoprotein cholesterol reduction. This review details the current state of evidence on lipid management in patients presenting with ACS, provides directions for identification of patients who may benefit from early escalation of lipid-lowering therapy, and discusses novel lipid-lowering medication that is currently under investigation in clinical trials. Moreover, a treatment algorithm aimed at attaining guideline-recommended low-density lipoprotein cholesterol levels is proposed. Despite important advances in the initial treatment and secondary prevention of ACS, ≈20% of ACS survivors experience a subsequent ischemic cardiovascular event within 24 months, and 5-year mortality ranges from 19% to 22%. Knowledge of the current state of evidence-based lipid management after ACS is of paramount importance to improve outcomes after ACS.

Original languageEnglish
Article numbere018897
JournalJournal of the American Heart Association
Issue number24
StatePublished - 15 Dec 2020


  • Acute coronary syndrome
  • Cardiovascular
  • Lipids


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