Lipid inclusions in cardiac myocytes-A rare case of cardiolipotoxicity

Rahul Gupta, Purva Ranchal, Sugandhi Mahajan, Rugved Pattarkine, Saikrishna Patibandla, John T. Fallon, Gregg M. Lanier

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The heart oxidizes fatty acids for its energy production. The physiological balance between fatty acid uptake and its oxidation prevents lipid accumulation in cardiac myocytes. However, accumulation of lipids due to various processes such as obesity, diabetes, heart failure, myocardial ischemia or infarction can result in damage to the heart tissue, also known as cardiolipotoxicity. We present a unique case of a 69-year-old gentleman with a history of heart failure and ventricular tachycardia. Endomyocardial biopsy to assess for restrictive cardiomyopathy/amyloid showed no evidence of amyloid, significant inflammation or fibrosis, but did show intracellular accumulation of significant amorphous material in most cardiac myocytes. We review the literature regarding the pathogenesis of cardiolipotoxicity, which has no definite cause or treatment yet identified.

Original languageEnglish
Pages (from-to)293-299
Number of pages7
JournalFuture Cardiology
Issue number2
StatePublished - Mar 2021
Externally publishedYes


  • cardiac steatosis
  • cardiolipotoxicity
  • cardiomyopathy
  • fat inclusions
  • lipotoxicity


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