Lipid-based nanotubes as functional architectures with embedded fluorescence and recognition capabilities

George John, Megan Mason, Pulickel M. Ajayan, Jonathan S. Dordick

Research output: Contribution to journalArticlepeer-review

63 Scopus citations

Abstract

A limited combinatorial strategy was used to synthesize a small library of soft lipid-based materials ranging from structurally unordered fibers to highly uniform nanotubes. The latter nanotubes are comprised of a bilayer structure with interdigitated alkyl chains associated through hydrophobic interactions. These tubes contain accessible 2,6-diaminopyridine linkers that can interact with thymidine and related nucleosides through multipoint hydrogen bonding, thereby quenching the intrinsic fluorescence of the aromatic linker. These results are the first example of a systematic strategy to design functional lipid nanotubes with precise structural and functional features.

Original languageEnglish
Pages (from-to)15012-15013
Number of pages2
JournalJournal of the American Chemical Society
Volume126
Issue number46
DOIs
StatePublished - 24 Nov 2004
Externally publishedYes

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