Lipid accumulation in smooth muscle cell lysosomes in primate atherosclerosis

S. Goldfischer, B. Schiller, H. Wolinsky

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

Cytochemical and ultrastructural examinations of the developing atherosclerotic lesions in hypercholesterolemic rhesus monkeys reveals that lipid is sequestered within lysosomes of aortic smooth muscle cells. A common pathway in the development of sclerotic arterial disease appears to be overloading of vascular smooth muscle cell lysosomes with a variety of metabolites. This may occur as a consequence of an excess of substrate or because of a congenital deficiency of a lysosomal hydrolase.

Original languageEnglish
Pages (from-to)497-502
Number of pages6
JournalAmerican Journal of Pathology
Volume78
Issue number3
StatePublished - 1975
Externally publishedYes

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