Linking genome to epigenome

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Recent epigenomic studies have identified significant differences between developmental stages and cell types. While the importance of epigenetic regulation has been increasingly recognized, it remains unclear how the global epigenetic patterns are established and maintained. Here I review a number of recent studies with the emphasis on the role of the genomic sequence in shaping the epigenetic landscape. These studies strongly suggest that the sequence information is important not just for controlling target specificity but for orchestrating the diversity of epigenetic patterns among different cell types. The epigenome is maintained by the complex network of a large number of interactions. Integrative approaches are needed to gain insights into these networks.

Original languageEnglish
Pages (from-to)297-309
Number of pages13
JournalWiley Interdisciplinary Reviews: Systems Biology and Medicine
Issue number3
StatePublished - May 2012
Externally publishedYes


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