Linkage of Gene for C2 Deficiency and the Major Histocompatibility Complex MHC in Man Family Study of a Further Case

Noorbibi K. Day; P. Rubinstein; D. Case; J. A. Hansen; R. A. Good; M. E. Walker; N. Tulchin; B. Dupont; C. Jersild

doi:10.1111/j.1423-0410.1976.tb02194.x

Linkage of Gene for C2 Deficiency and the Major Histocompatibility Complex MHC in Man Family Study of a Further Case

Noorbibi K. Day, P. Rubinstein, D. Case, J. A. Hansen, R. A. Good, M. E. Walker, N. Tulchin, B. Dupont, C. Jersild

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16 Scopus citations

Abstract

Abstract. Close linkage between HL‐A and C2 deficiency was first reported by Fu and co‐workers in 1974. We present here a pedigree of a 31‐year‐old C2‐deficient individual with clinical manifestations of Hodgkins disease. The following markers were tested: C2 levels, factor B polymorphism, blood groups, and enzyme typing. In addition to close linkage between HL‐A and C2 deficiency, both parents were heterozygous for Bf (HL‐A linked, electrophoretic variation of B). The two HL‐A haplotypes closely linked to C2 deficiency are different: 2,W18 and W24,W18. They share, however, the SD2 antigen W18 and the LD type 7a.

Original language	English
Pages (from-to)	96-102
Number of pages	7
Journal	Vox Sanguinis
Volume	31
Issue number	2
DOIs	https://doi.org/10.1111/j.1423-0410.1976.tb02194.x
State	Published - Aug 1976
Externally published	Yes

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title = "Linkage of Gene for C2 Deficiency and the Major Histocompatibility Complex MHC in Man Family Study of a Further Case",

abstract = "Abstract. Close linkage between HL‐A and C2 deficiency was first reported by Fu and co‐workers in 1974. We present here a pedigree of a 31‐year‐old C2‐deficient individual with clinical manifestations of Hodgkins disease. The following markers were tested: C2 levels, factor B polymorphism, blood groups, and enzyme typing. In addition to close linkage between HL‐A and C2 deficiency, both parents were heterozygous for Bf (HL‐A linked, electrophoretic variation of B). The two HL‐A haplotypes closely linked to C2 deficiency are different: 2,W18 and W24,W18. They share, however, the SD2 antigen W18 and the LD type 7a.",

author = "Day, \{Noorbibi K.\} and P. Rubinstein and D. Case and Hansen, \{J. A.\} and Good, \{R. A.\} and Walker, \{M. E.\} and N. Tulchin and B. Dupont and C. Jersild",

year = "1976",

month = aug,

doi = "10.1111/j.1423-0410.1976.tb02194.x",

language = "English",

volume = "31",

pages = "96--102",

journal = "Vox Sanguinis",

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TY - JOUR

T1 - Linkage of Gene for C2 Deficiency and the Major Histocompatibility Complex MHC in Man Family Study of a Further Case

AU - Day, Noorbibi K.

AU - Rubinstein, P.

AU - Case, D.

AU - Hansen, J. A.

AU - Good, R. A.

AU - Walker, M. E.

AU - Tulchin, N.

AU - Dupont, B.

AU - Jersild, C.

PY - 1976/8

Y1 - 1976/8

N2 - Abstract. Close linkage between HL‐A and C2 deficiency was first reported by Fu and co‐workers in 1974. We present here a pedigree of a 31‐year‐old C2‐deficient individual with clinical manifestations of Hodgkins disease. The following markers were tested: C2 levels, factor B polymorphism, blood groups, and enzyme typing. In addition to close linkage between HL‐A and C2 deficiency, both parents were heterozygous for Bf (HL‐A linked, electrophoretic variation of B). The two HL‐A haplotypes closely linked to C2 deficiency are different: 2,W18 and W24,W18. They share, however, the SD2 antigen W18 and the LD type 7a.

AB - Abstract. Close linkage between HL‐A and C2 deficiency was first reported by Fu and co‐workers in 1974. We present here a pedigree of a 31‐year‐old C2‐deficient individual with clinical manifestations of Hodgkins disease. The following markers were tested: C2 levels, factor B polymorphism, blood groups, and enzyme typing. In addition to close linkage between HL‐A and C2 deficiency, both parents were heterozygous for Bf (HL‐A linked, electrophoretic variation of B). The two HL‐A haplotypes closely linked to C2 deficiency are different: 2,W18 and W24,W18. They share, however, the SD2 antigen W18 and the LD type 7a.

UR - https://www.scopus.com/pages/publications/0017071520

U2 - 10.1111/j.1423-0410.1976.tb02194.x

DO - 10.1111/j.1423-0410.1976.tb02194.x

M3 - Article

C2 - 133535

AN - SCOPUS:0017071520

SN - 0042-9007

VL - 31

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EP - 102

JO - Vox Sanguinis

JF - Vox Sanguinis

IS - 2

ER -

Linkage of Gene for C2 Deficiency and the Major Histocompatibility Complex MHC in Man Family Study of a Further Case

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