Linkage disequilibrium study of microsatellite markers on chromosome 6 and schizophrenia

Hong Deng, Xiehe Liu, Guiqing Cai, Henry Terwedow, Zhaoxi Wang, Xin Xu

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Objective To explore the relationship between the microsatellite markers on chromosome 6 and schizophrenia by linkage disequilibrium analysis. Methods Twenty-eight microsatellite markers on chromosome 6 were evaluated in 115 affected-sib-pair and trios families. Linkage disequilibrium analysis was conducted according to diagnostic categories, Positive and Negative Syndrome Scale (PANSS) and other clinical data by XDT and MAPMAKER/SIBS software system. Results Significant P value (P<0.005) was found in all the four diagnostic categories. Only the locus of D6S1960 showed positive P value (P<0.05) in all the subgroups divided by PANSS scale and the age of onset. Conclusion The area around D6S1960 in short arm of chromosome 6 may contain susceptibility gene of schizophrenia.

Original languageEnglish
Pages (from-to)6-9
Number of pages4
JournalChinese Journal of Medical Genetics
Volume19
Issue number1
StatePublished - 2002
Externally publishedYes

Keywords

  • Chromosome 6
  • Linkage disequilibrium
  • Schizophrenia

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