@article{1124b16a697b4891823429fedbc21a1d,
title = "Linkage and linkage disequilibrium mapping of ERP and EEG phenotypes",
abstract = "Linkage analyses of highly heritable electrophysiological phenotypes (EEG, ERP) that can potentially identify individuals at risk for alcoholism were performed on a large sample of families with a high density of alcohol dependence as part of the Collaborative Study on the Genetics of Alcoholism (COGA); these genetic findings are summarized. Quantitative trait loci (QTLs) were identified for several ERP characteristics (P300, N100, N400) and for the beta frequencies of the EEG where we report linkage and linkage disequilibrium at a GABAA receptor gene on chromosome 4. Genetic analyses of ERPs suggest that several regions of the human genome contain genetic loci related to the generation of N100, N400 and P300, which are possible candidate loci underlying the functional organization of human neuroelectric activity. The advent of genomics and proteomics and a fuller understanding of gene regulation, will open new horizons on the critical electrical events so essential for human brain function.",
keywords = "EEG, ERP, Genetics, P300",
author = "Bernice Porjesz and Henri Begleiter and Kongming Wang and Laura Almasy and Chorlian, {David B.} and Stimus, {Arthur T.} and Samuel Kuperman and O'Connor, {Sean J.} and John Rohrbaugh and Bauer, {Lance O.} and Edenberg, {Howard J.} and Alison Goate and Rice, {John P.} and Theodore Reich",
note = "Funding Information: The Collaborative Study on the Genetics of Alcoholism (COGA) (H. Begleiter, SUNY HSCB Principal Investigator, T. Reich, Washington University, Co-Principal Investigator) includes nine different centers where data collection, analysis, and/or storage takes place. The nine sites and Principal Investigators and Co-Investigators are: Indiana University (T.-K. Li, J. Nurnberger Jr., P.M. Conneally, H. Edenberg); University of Iowa (R. Crowe, S. Kuperman); University of California at San Diego (M. Schuckit); University of Connecticut (V. Hesselbrock); State University of New York, Health Sciences Center at Brooklyn (B. Porjesz, H. Begleiter); Washington University in St. Louis (T. Reich, C.R. Cloninger, J. Rice, A. Goate); Howard University (R. Taylor); Rutgers University (J. Tischfield); and Southwest Foundation (L. Almasy). This national collaborative study is supported by the NIH Grant U10AA08403 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA). ",
year = "2002",
month = oct,
doi = "10.1016/S0301-0511(02)00060-1",
language = "English",
volume = "61",
pages = "229--248",
journal = "Biological Psychology",
issn = "0301-0511",
publisher = "Elsevier",
number = "1-2",
}