Linkage analysis of a complex pedigree with severe bipolar disorder, using a Markov chain Monte Carlo method

C. Garner; L. A. McInnes; S. K. Service; M. Spesny; E. Fournier; P. Leon; N. B. Freimer

doi:10.1086/319517

Linkage analysis of a complex pedigree with severe bipolar disorder, using a Markov chain Monte Carlo method

C. Garner
, L. A. McInnes
, S. K. Service
, M. Spesny
, E. Fournier
, P. Leon
, N. B. Freimer

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

Recently developed algorithms permit nonparametric linkage analysis of large, complex pedigrees with multiple inbreeding loops. We have used one such algorithm, implemented in the package Sim Walk2, to reanalyze previously published genome-screen data from a Costa Rican kindred segregating for severe bipolar disorder. Our results are consistent with previous linkage findings on chromosome 18 and suggest a new locus on chromosome 5 that was not identified using traditional linkage analysis.

Original language	English
Pages (from-to)	1061-1064
Number of pages	4
Journal	American Journal of Human Genetics
Volume	68
Issue number	4
DOIs	https://doi.org/10.1086/319517
State	Published - 2001
Externally published	Yes

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10.1086/319517

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@article{6528eee3670949bc879e4d2b052662ca,

title = "Linkage analysis of a complex pedigree with severe bipolar disorder, using a Markov chain Monte Carlo method",

abstract = "Recently developed algorithms permit nonparametric linkage analysis of large, complex pedigrees with multiple inbreeding loops. We have used one such algorithm, implemented in the package Sim Walk2, to reanalyze previously published genome-screen data from a Costa Rican kindred segregating for severe bipolar disorder. Our results are consistent with previous linkage findings on chromosome 18 and suggest a new locus on chromosome 5 that was not identified using traditional linkage analysis.",

author = "C. Garner and McInnes, \{L. A.\} and Service, \{S. K.\} and M. Spesny and E. Fournier and P. Leon and Freimer, \{N. B.\}",

note = "Funding Information: This work was supported by the National Institutes of Health (NIH) grants MH-01748, to L.A.M., and MH-00916 and MH-49499, to N.B.F.; by Fundacion de la Universidad de Costa Rica para la Investigacion (FUNDEVI); and by the vice rectory of research of the University of Costa Rica. C.G. is supported by NIH grant GM-40282. We thank the Wellcome Trust Centre for Human Genetics, for the use of computer resources, and Eric Sobel and Lodewijk Sandkuijl, for helpful comments. We thank the families who participated in this project and Costa Rican institutions that made this work possible: Hospital Nacional Psiquiatr{\'i}co, Hospital Calderon Guardia, Caja Costarricense de Seguro Social, Archivo Nacional de Costa Rica, and Iglesia Catolica de Costa Rica. A complete list of genomewide results can be obtained from N.B.F. ",

year = "2001",

doi = "10.1086/319517",

language = "English",

volume = "68",

pages = "1061--1064",

journal = "American Journal of Human Genetics",

issn = "0002-9297",

publisher = "Cell Press",

number = "4",

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TY - JOUR

T1 - Linkage analysis of a complex pedigree with severe bipolar disorder, using a Markov chain Monte Carlo method

AU - Garner, C.

AU - McInnes, L. A.

AU - Service, S. K.

AU - Spesny, M.

AU - Fournier, E.

AU - Leon, P.

AU - Freimer, N. B.

N1 - Funding Information: This work was supported by the National Institutes of Health (NIH) grants MH-01748, to L.A.M., and MH-00916 and MH-49499, to N.B.F.; by Fundacion de la Universidad de Costa Rica para la Investigacion (FUNDEVI); and by the vice rectory of research of the University of Costa Rica. C.G. is supported by NIH grant GM-40282. We thank the Wellcome Trust Centre for Human Genetics, for the use of computer resources, and Eric Sobel and Lodewijk Sandkuijl, for helpful comments. We thank the families who participated in this project and Costa Rican institutions that made this work possible: Hospital Nacional Psiquiatríco, Hospital Calderon Guardia, Caja Costarricense de Seguro Social, Archivo Nacional de Costa Rica, and Iglesia Catolica de Costa Rica. A complete list of genomewide results can be obtained from N.B.F.

PY - 2001

Y1 - 2001

N2 - Recently developed algorithms permit nonparametric linkage analysis of large, complex pedigrees with multiple inbreeding loops. We have used one such algorithm, implemented in the package Sim Walk2, to reanalyze previously published genome-screen data from a Costa Rican kindred segregating for severe bipolar disorder. Our results are consistent with previous linkage findings on chromosome 18 and suggest a new locus on chromosome 5 that was not identified using traditional linkage analysis.

AB - Recently developed algorithms permit nonparametric linkage analysis of large, complex pedigrees with multiple inbreeding loops. We have used one such algorithm, implemented in the package Sim Walk2, to reanalyze previously published genome-screen data from a Costa Rican kindred segregating for severe bipolar disorder. Our results are consistent with previous linkage findings on chromosome 18 and suggest a new locus on chromosome 5 that was not identified using traditional linkage analysis.

UR - https://www.scopus.com/pages/publications/0035069310

U2 - 10.1086/319517

DO - 10.1086/319517

M3 - Article

C2 - 11222106

AN - SCOPUS:0035069310

SN - 0002-9297

VL - 68

SP - 1061

EP - 1064

JO - American Journal of Human Genetics

JF - American Journal of Human Genetics

IS - 4

ER -

Linkage analysis of a complex pedigree with severe bipolar disorder, using a Markov chain Monte Carlo method

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