@article{6528eee3670949bc879e4d2b052662ca,
title = "Linkage analysis of a complex pedigree with severe bipolar disorder, using a Markov chain Monte Carlo method",
abstract = "Recently developed algorithms permit nonparametric linkage analysis of large, complex pedigrees with multiple inbreeding loops. We have used one such algorithm, implemented in the package Sim Walk2, to reanalyze previously published genome-screen data from a Costa Rican kindred segregating for severe bipolar disorder. Our results are consistent with previous linkage findings on chromosome 18 and suggest a new locus on chromosome 5 that was not identified using traditional linkage analysis.",
author = "C. Garner and McInnes, {L. A.} and Service, {S. K.} and M. Spesny and E. Fournier and P. Leon and Freimer, {N. B.}",
note = "Funding Information: This work was supported by the National Institutes of Health (NIH) grants MH-01748, to L.A.M., and MH-00916 and MH-49499, to N.B.F.; by Fundacion de la Universidad de Costa Rica para la Investigacion (FUNDEVI); and by the vice rectory of research of the University of Costa Rica. C.G. is supported by NIH grant GM-40282. We thank the Wellcome Trust Centre for Human Genetics, for the use of computer resources, and Eric Sobel and Lodewijk Sandkuijl, for helpful comments. We thank the families who participated in this project and Costa Rican institutions that made this work possible: Hospital Nacional Psiquiatr{\'i}co, Hospital Calderon Guardia, Caja Costarricense de Seguro Social, Archivo Nacional de Costa Rica, and Iglesia Catolica de Costa Rica. A complete list of genomewide results can be obtained from N.B.F. ",
year = "2001",
doi = "10.1086/319517",
language = "English",
volume = "68",
pages = "1061--1064",
journal = "American Journal of Human Genetics",
issn = "0002-9297",
publisher = "Cell Press",
number = "4",
}