Linkage analyses of IQ in the Collaborative Study on the Genetics of Alcoholism (COGA) sample

Danielle M. Dick, Fazil Aliev, Laura Bierut, Alison Goate, John Rice, Anthony Hinrichs, Sarah Bertelsen, Jen C. Wang, Gerald Dunn, Sam Kuperman, Marc Schuckit, John Nurnberger, Bernice Porjesz, Henri Begleiter, John Kramer, Victor Hesselbrock

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Intelligence, as measured by standardized psychological tests, has been shown to be highly heritable, though identifying specific genes influencing general intelligence has proven difficult. We conducted genome-wide linkage analyses to identify chromosomal regions containing genes influencing intelligence, as measured by WAIS full-scale IQ (FSIQ), performance IQ (PIQ) and verbal IQ (VIQ). Non-parametric multipoint linkage analyses were conducted with Merlin-regress software, using a sample of 1111 genotyped and phenotyped individuals from 201 families, ascertained as part of the Collaborative Study on the Genetics of Alcoholism (COGA). The strongest evidence of linkage was obtained for FSIQ on chromosome 6 (LOD = 3.28, 12 cM) near the marker D6S1006. This region was also implicated with suggestive linkage in a recently published genome screen of IQ in Australian and Dutch twin pairs, and it has been implicated in linkage studies of developmental dyslexia. Our findings provide further support that chromosome 6p contains gene(s) affecting intelligence.

Original languageEnglish
Pages (from-to)77-86
Number of pages10
JournalBehavior Genetics
Issue number1
StatePublished - Jan 2006
Externally publishedYes


  • Cognitive ability
  • Genetics
  • IQ
  • Intelligence
  • Linkage analyses


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