Lineage-Restricted Regulation of SCD and Fatty Acid Saturation by MITF Controls Melanoma Phenotypic Plasticity

Yurena Vivas-García, Paola Falletta, Jana Liebing, Pakavarin Louphrasitthiphol, Yongmei Feng, Jagat Chauhan, David A. Scott, Nicole Glodde, Ana Chocarro-Calvo, Sarah Bonham, Andrei L. Osterman, Roman Fischer, Ze'ev Ronai, Custodia García-Jiménez, Michael Hölzel, Colin R. Goding

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Vivas-Garcia et al. reveal that in melanoma, expression of the long-chain fatty acid desaturase SCD is controlled by the lineage-addiction oncogene MITF. The MITF-SCD axis suppresses stress and inflammatory signaling and inhibits invasion and metastatic dissemination, whereas low SCD activity imposes and stabilizes an MITFLow de-differentiated, invasive phenotype.

Original languageEnglish
Pages (from-to)120-137.e9
JournalMolecular Cell
Volume77
Issue number1
DOIs
StatePublished - 2 Jan 2020
Externally publishedYes

Keywords

  • ATF4
  • MITF
  • fatty acid saturation
  • melanoma
  • metastatic dissemination
  • phenotype switching
  • stearoyl CoA desaturase

Fingerprint

Dive into the research topics of 'Lineage-Restricted Regulation of SCD and Fatty Acid Saturation by MITF Controls Melanoma Phenotypic Plasticity'. Together they form a unique fingerprint.

Cite this