TY - JOUR
T1 - Limited association between Disrupted in Schizophrenia 1 (DISC1) gene and bipolar disorder in the Chinese population
AU - Xiao, Yue
AU - Zhang, Jing
AU - Wang, Yang
AU - Wang, Peng
AU - Li, Xingwang
AU - Ji, Jue
AU - Yang, Fengping
AU - Feng, Guoyin
AU - He, Lin
AU - He, Guang
PY - 2011/2
Y1 - 2011/2
N2 - Objective: Bipolar disorder is a common, severe, and recurrent psychiatric disorder. The Disrupted in Schizophrenia 1 (DISC1) gene has been associated with the risk of schizophrenia, schizoaffective disorder, bipolar disorder, major depression, autism, and Asperger syndrome in different populations. Here, we report the first association study for the DISC1 with bipolar disorder in Chinese cohorts. Methods: We conducted a case-control study and genotyped 12 single nucleotide polymorphisms in 506 bipolar patients and 507 controls recruited from Anhui province in China. The genotyping procedure was carried on the ABI 7900 DNA detection platform by using TaqMan probe technology. RESULT: Although the data did not show association between any individual single nucleotide polymorphism in the DISC1 gene and bipolar disorder, a haplotype [rs2738864 (C)-rs16841582 (C)] was found to be associated with the disorder (P=0.0191). Conclusion: This finding provides evidence supporting the role of DISC1 gene in bipolar disorder, and shows the presence of population heterogeneity.
AB - Objective: Bipolar disorder is a common, severe, and recurrent psychiatric disorder. The Disrupted in Schizophrenia 1 (DISC1) gene has been associated with the risk of schizophrenia, schizoaffective disorder, bipolar disorder, major depression, autism, and Asperger syndrome in different populations. Here, we report the first association study for the DISC1 with bipolar disorder in Chinese cohorts. Methods: We conducted a case-control study and genotyped 12 single nucleotide polymorphisms in 506 bipolar patients and 507 controls recruited from Anhui province in China. The genotyping procedure was carried on the ABI 7900 DNA detection platform by using TaqMan probe technology. RESULT: Although the data did not show association between any individual single nucleotide polymorphism in the DISC1 gene and bipolar disorder, a haplotype [rs2738864 (C)-rs16841582 (C)] was found to be associated with the disorder (P=0.0191). Conclusion: This finding provides evidence supporting the role of DISC1 gene in bipolar disorder, and shows the presence of population heterogeneity.
KW - DISC1
KW - Han Chinese population
KW - association, bipolar disorder
KW - case-control analysis
UR - http://www.scopus.com/inward/record.url?scp=78650787073&partnerID=8YFLogxK
U2 - 10.1097/YPG.0b013e32834135d2
DO - 10.1097/YPG.0b013e32834135d2
M3 - Article
C2 - 21222298
AN - SCOPUS:78650787073
SN - 0955-8829
VL - 21
SP - 42
EP - 46
JO - Psychiatric Genetics
JF - Psychiatric Genetics
IS - 1
ER -