Lifelong corticosterone level determines age-related decline in neurogenesis and memory

M. F. Montaron; E. Drapeau; D. Dupret; P. Kitchener; C. Aurousseau; M. Le Moal; P. V. Piazza; D. N. Abrous

doi:10.1016/j.neurobiolaging.2005.02.014

Lifelong corticosterone level determines age-related decline in neurogenesis and memory

M. F. Montaron, E. Drapeau, D. Dupret, P. Kitchener, C. Aurousseau, M. Le Moal, P. V. Piazza, D. N. Abrous

Research output: Contribution to journal › Article › peer-review

166 Scopus citations

Abstract

Ageing is accompanied by an alteration of spatial memory, a decline in hippocampal neurogenesis and a dysregulation of the hypothalamic-pituitary axis (HPA) leading to elevated levels of circulating corticosterone. However, the role of the HPA axis in age-related decline in cognitive functions and in neurogenesis decline remains unclear. We found that suppression of glucocorticoids secretion from midlife to the rest of the animals' life increases neurogenesis in old animals and prevents the emergence of age-related memory disorders. Reciprocally, aged rats with a chronic upregulation of the HPA axis exhibit not only spatial memory impairments but also very low levels of hippocampal cell proliferation and survival. Altogether, these results indicate that the extent of lifetime exposure to glucocorticoids determines the extent of age-related decline in hippocampal neurogenesis and consequently age-related cognitive dysfunctions.

Original language	English
Pages (from-to)	645-654
Number of pages	10
Journal	Neurobiology of Aging
Volume	27
Issue number	4
DOIs	https://doi.org/10.1016/j.neurobiolaging.2005.02.014
State	Published - Apr 2006
Externally published	Yes

Keywords

Ageing
Corticosterone
Hippocampus
Neurogenesis
Spatial learning

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10.1016/j.neurobiolaging.2005.02.014

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title = "Lifelong corticosterone level determines age-related decline in neurogenesis and memory",

abstract = "Ageing is accompanied by an alteration of spatial memory, a decline in hippocampal neurogenesis and a dysregulation of the hypothalamic-pituitary axis (HPA) leading to elevated levels of circulating corticosterone. However, the role of the HPA axis in age-related decline in cognitive functions and in neurogenesis decline remains unclear. We found that suppression of glucocorticoids secretion from midlife to the rest of the animals' life increases neurogenesis in old animals and prevents the emergence of age-related memory disorders. Reciprocally, aged rats with a chronic upregulation of the HPA axis exhibit not only spatial memory impairments but also very low levels of hippocampal cell proliferation and survival. Altogether, these results indicate that the extent of lifetime exposure to glucocorticoids determines the extent of age-related decline in hippocampal neurogenesis and consequently age-related cognitive dysfunctions.",

keywords = "Ageing, Corticosterone, Hippocampus, Neurogenesis, Spatial learning",

author = "Montaron, {M. F.} and E. Drapeau and D. Dupret and P. Kitchener and C. Aurousseau and {Le Moal}, M. and Piazza, {P. V.} and Abrous, {D. N.}",

note = "Funding Information: The authors would like to thank Mrs. Donat M.C. for her technical help. Supported by INSERM, CNRS (UR259-257-8BG01E), la «Fondation pour la Recherche Medicale», La “R{\'e}gion Aquitaine” and University of Bordeaux II.",

year = "2006",

month = apr,

doi = "10.1016/j.neurobiolaging.2005.02.014",

language = "English",

volume = "27",

pages = "645--654",

journal = "Neurobiology of Aging",

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T1 - Lifelong corticosterone level determines age-related decline in neurogenesis and memory

AU - Montaron, M. F.

AU - Drapeau, E.

AU - Dupret, D.

AU - Kitchener, P.

AU - Aurousseau, C.

AU - Le Moal, M.

AU - Piazza, P. V.

AU - Abrous, D. N.

N1 - Funding Information: The authors would like to thank Mrs. Donat M.C. for her technical help. Supported by INSERM, CNRS (UR259-257-8BG01E), la «Fondation pour la Recherche Medicale», La “Région Aquitaine” and University of Bordeaux II.

PY - 2006/4

Y1 - 2006/4

N2 - Ageing is accompanied by an alteration of spatial memory, a decline in hippocampal neurogenesis and a dysregulation of the hypothalamic-pituitary axis (HPA) leading to elevated levels of circulating corticosterone. However, the role of the HPA axis in age-related decline in cognitive functions and in neurogenesis decline remains unclear. We found that suppression of glucocorticoids secretion from midlife to the rest of the animals' life increases neurogenesis in old animals and prevents the emergence of age-related memory disorders. Reciprocally, aged rats with a chronic upregulation of the HPA axis exhibit not only spatial memory impairments but also very low levels of hippocampal cell proliferation and survival. Altogether, these results indicate that the extent of lifetime exposure to glucocorticoids determines the extent of age-related decline in hippocampal neurogenesis and consequently age-related cognitive dysfunctions.

AB - Ageing is accompanied by an alteration of spatial memory, a decline in hippocampal neurogenesis and a dysregulation of the hypothalamic-pituitary axis (HPA) leading to elevated levels of circulating corticosterone. However, the role of the HPA axis in age-related decline in cognitive functions and in neurogenesis decline remains unclear. We found that suppression of glucocorticoids secretion from midlife to the rest of the animals' life increases neurogenesis in old animals and prevents the emergence of age-related memory disorders. Reciprocally, aged rats with a chronic upregulation of the HPA axis exhibit not only spatial memory impairments but also very low levels of hippocampal cell proliferation and survival. Altogether, these results indicate that the extent of lifetime exposure to glucocorticoids determines the extent of age-related decline in hippocampal neurogenesis and consequently age-related cognitive dysfunctions.

KW - Ageing

KW - Corticosterone

KW - Hippocampus

KW - Neurogenesis

KW - Spatial learning

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AN - SCOPUS:33344478060

SN - 0197-4580

VL - 27

SP - 645

EP - 654

JO - Neurobiology of Aging

JF - Neurobiology of Aging

IS - 4

ER -

Lifelong corticosterone level determines age-related decline in neurogenesis and memory

Abstract

Keywords

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