TY - JOUR
T1 - Lichen planus in two immunodeficient hosts
AU - Flamenbaum, Helen S.
AU - Safai, Bijan
AU - Siegal, Frederick P.
AU - Pahwa, Savita
N1 - Funding Information:
From the Dermatology and Clinical Immunobiology Services of the Memorial Sloan-Kettering Cancer Center. Supported in part by U.S. Public Health Service grant CA-19267, Witty's Fund, Chesebrough-Pond's, Inc., Handmacher Founda-tion, Inc., Dickson's Fund, Mirsky's Fund, and Robert S. Sinn Fund. Accepted for publication Aug. 20, 1981. Reprint requests to: Dr. Bijan Safai, Memorial Sloan-Kettering Cancer Center, 1275 York Ave., New York, NY 10021. *Present address: Division of Clinical Immunology, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029.
PY - 1982
Y1 - 1982
N2 - The exact pathogenic mechanism involved in lichen planus (LP) remains obscure. Two patients who have severe immunodeficiency diseases and who developed LP during the course of their illness are reported here. Both patients had hypogammaglobulinemia and disturbed immune function prior to the development of LP. Although such an association could be coincidental, the development of LP may be related to the underlying immune disturbances. Association of LP with several other disorders of the immune system has been previously observed. Other evidence for the possible involvement of an immunopathogenic mechanism in LP includes (1) deposition of immunoglobulin within the colloid bodies and at the dermoepidermal junction, (2) predominantly T cell dermal infiltrate in LP lesions, and (3) existence of clinical and histologic similarities between graft-versus-host disease and LP.
AB - The exact pathogenic mechanism involved in lichen planus (LP) remains obscure. Two patients who have severe immunodeficiency diseases and who developed LP during the course of their illness are reported here. Both patients had hypogammaglobulinemia and disturbed immune function prior to the development of LP. Although such an association could be coincidental, the development of LP may be related to the underlying immune disturbances. Association of LP with several other disorders of the immune system has been previously observed. Other evidence for the possible involvement of an immunopathogenic mechanism in LP includes (1) deposition of immunoglobulin within the colloid bodies and at the dermoepidermal junction, (2) predominantly T cell dermal infiltrate in LP lesions, and (3) existence of clinical and histologic similarities between graft-versus-host disease and LP.
UR - http://www.scopus.com/inward/record.url?scp=0020076294&partnerID=8YFLogxK
U2 - 10.1016/S0190-9622(82)70081-7
DO - 10.1016/S0190-9622(82)70081-7
M3 - Article
C2 - 6980233
AN - SCOPUS:0020076294
SN - 0190-9622
VL - 6
SP - 918
EP - 920
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 5
ER -