LFA-1, LFA-2 and LFA-3 antigens are involved in CTL-target conjugation

A. M. Krensky, E. Robbins, T. A. Springer, S. J. Burakoff

Research output: Contribution to journalArticlepeer-review

177 Scopus citations


Three cell surface antigens associated with the CTL-target cell interaction were previously identified by generation of mAb against OKT4+, HLA-DR-specific CTL, and selection for inhibition of cytolysis in a 51Cr-release assay. In this report, we showed that these mAb inhibit cytolysis by blocking CTL-target cell conjugate formation. It appears that LFA-1, LFA-2, and LFA-3 are cell surface structures involved in strengthening effector-target adhesion that accompanies antigen-specific recognition.

Original languageEnglish
Pages (from-to)2180-2182
Number of pages3
JournalJournal of Immunology
Issue number5
StatePublished - 1984
Externally publishedYes


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