LFA-1, LFA-2 and LFA-3 antigens are involved in CTL-target conjugation

A. M. Krensky; E. Robbins; T. A. Springer; S. J. Burakoff

LFA-1, LFA-2 and LFA-3 antigens are involved in CTL-target conjugation

A. M. Krensky, E. Robbins, T. A. Springer, S. J. Burakoff

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197 Scopus citations

Abstract

Three cell surface antigens associated with the CTL-target cell interaction were previously identified by generation of mAb against OKT4⁺, HLA-DR-specific CTL, and selection for inhibition of cytolysis in a ⁵¹Cr-release assay. In this report, we showed that these mAb inhibit cytolysis by blocking CTL-target cell conjugate formation. It appears that LFA-1, LFA-2, and LFA-3 are cell surface structures involved in strengthening effector-target adhesion that accompanies antigen-specific recognition.

Original language	English
Pages (from-to)	2180-2182
Number of pages	3
Journal	Journal of Immunology
Volume	132
Issue number	5
State	Published - 1984
Externally published	Yes

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abstract = "Three cell surface antigens associated with the CTL-target cell interaction were previously identified by generation of mAb against OKT4+, HLA-DR-specific CTL, and selection for inhibition of cytolysis in a 51Cr-release assay. In this report, we showed that these mAb inhibit cytolysis by blocking CTL-target cell conjugate formation. It appears that LFA-1, LFA-2, and LFA-3 are cell surface structures involved in strengthening effector-target adhesion that accompanies antigen-specific recognition.",

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year = "1984",

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AU - Krensky, A. M.

AU - Robbins, E.

AU - Springer, T. A.

AU - Burakoff, S. J.

PY - 1984

Y1 - 1984

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AB - Three cell surface antigens associated with the CTL-target cell interaction were previously identified by generation of mAb against OKT4+, HLA-DR-specific CTL, and selection for inhibition of cytolysis in a 51Cr-release assay. In this report, we showed that these mAb inhibit cytolysis by blocking CTL-target cell conjugate formation. It appears that LFA-1, LFA-2, and LFA-3 are cell surface structures involved in strengthening effector-target adhesion that accompanies antigen-specific recognition.

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ER -

LFA-1, LFA-2 and LFA-3 antigens are involved in CTL-target conjugation

Abstract

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