LFA-1 expression on target cells promotes human immunodeficiency virus type 1 infection and transmission

C. E. Hioe, Jr Chien, C. Lu, T. A. Springer, X. H. Wang, J. Bandres, M. Tuen

Research output: Contribution to journalArticlepeer-review

65 Scopus citations


While CD4 and the chemokine receptors are the principal receptors for human immunodeficiency virus (HIV), other cellular proteins, such as LFA-1, are also involved in HIV infection. LFA-1 and its ligands, ICAM-1, ICAM-2, and ICAM-3, can be expressed on the cells infected by HIV, as well as on the HIV virions themselves. To examine the role of LFA-1 expressed on target cells in HIV infection, Jurkat-derived Jβ2.7 T-cell lines that express either wild-type LFA-1, a constitutively active mutant LFA-1, or no LFA-1 were used. The presence of wild-type LFA-1 enhanced the initial processes of HIV infection, as well as the subsequent replication and transmission from cell to cell. In contrast, the constitutively active LFA-1 mutant failed to promote virus replication and spread, even though this mutant could help HIV enter cells and establish the initial infection. This study clearly demonstrates the contribution of LFA-1 in the different stages of HIV infection. Moreover, not only is LFA-1 expression important for initial HIV-cell interaction, subsequent replication, and transmission, but its activity must also be properly regulated.

Original languageEnglish
Pages (from-to)1077-1082
Number of pages6
JournalJournal of Virology
Issue number2
StatePublished - 2001
Externally publishedYes


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