Abstract
Lewy bodies are considered to be the hallmark pathological features of idiopathic Parkinson's disease and dementia with Lewy bodies. However, they are also present in a variety of other disorders of the central nervous system, most notably in Alzheimer's disease, and in neurologically normal aged individuals. More recently, α-synuclein-associated neuropathology has been identified in miscellaneous disorders, such as Niemann-Pick type C disease, GBA-associated Parkinson's disease and PLA2G6-associated disorders. Here, we conclude that alterations related to dysfunctions of lysosomes and autophagy may contribute to protein aggregation associated with aging, age-related disorders and α-synuclein-mediated neurodegeneration.
| Original language | English |
|---|---|
| Title of host publication | Neurodegeneration |
| Subtitle of host publication | The Molecular Pathology of Dementia and Movement Disorders: Second Edition |
| Publisher | Wiley-Blackwell |
| Pages | 238-241 |
| Number of pages | 4 |
| ISBN (Print) | 9781405196932 |
| DOIs | |
| State | Published - 21 Sep 2011 |
Keywords
- Aging processes
- Lewy bodies
- Lysosomal and autophagy dysfunction
- Neuroaxonal dystrophy
- Neurodegeneration
- Neurofibrillary tangles
- PLA2G6-associated disorders
- α-synuclein
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