Lewy Bodies in Conditions other than Disorders of α-Synuclein

Coro Paisán-Ruiz, Laura Parkkinen, Tamas Revesz

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations


Lewy bodies are considered to be the hallmark pathological features of idiopathic Parkinson's disease and dementia with Lewy bodies. However, they are also present in a variety of other disorders of the central nervous system, most notably in Alzheimer's disease, and in neurologically normal aged individuals. More recently, α-synuclein-associated neuropathology has been identified in miscellaneous disorders, such as Niemann-Pick type C disease, GBA-associated Parkinson's disease and PLA2G6-associated disorders. Here, we conclude that alterations related to dysfunctions of lysosomes and autophagy may contribute to protein aggregation associated with aging, age-related disorders and α-synuclein-mediated neurodegeneration.

Original languageEnglish
Title of host publicationNeurodegeneration
Subtitle of host publicationThe Molecular Pathology of Dementia and Movement Disorders: Second Edition
Number of pages4
ISBN (Print)9781405196932
StatePublished - 21 Sep 2011


  • Aging processes
  • Lewy bodies
  • Lysosomal and autophagy dysfunction
  • Neuroaxonal dystrophy
  • Neurodegeneration
  • Neurofibrillary tangles
  • PLA2G6-associated disorders
  • α-synuclein


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