Lewy Bodies in Conditions other than Disorders of α-Synuclein

Coro Paisán-Ruiz; Laura Parkkinen; Tamas Revesz

doi:10.1002/9781444341256.ch23

Lewy Bodies in Conditions other than Disorders of α-Synuclein

Coro Paisán-Ruiz, Laura Parkkinen, Tamas Revesz

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Scopus citations

Abstract

Lewy bodies are considered to be the hallmark pathological features of idiopathic Parkinson's disease and dementia with Lewy bodies. However, they are also present in a variety of other disorders of the central nervous system, most notably in Alzheimer's disease, and in neurologically normal aged individuals. More recently, α-synuclein-associated neuropathology has been identified in miscellaneous disorders, such as Niemann-Pick type C disease, GBA-associated Parkinson's disease and PLA2G6-associated disorders. Here, we conclude that alterations related to dysfunctions of lysosomes and autophagy may contribute to protein aggregation associated with aging, age-related disorders and α-synuclein-mediated neurodegeneration.

Original language	English
Title of host publication	Neurodegeneration
Subtitle of host publication	The Molecular Pathology of Dementia and Movement Disorders: Second Edition
Publisher	Wiley-Blackwell
Pages	238-241
Number of pages	4
ISBN (Print)	9781405196932
DOIs	https://doi.org/10.1002/9781444341256.ch23
State	Published - 21 Sep 2011

Keywords

Aging processes
Lewy bodies
Lysosomal and autophagy dysfunction
Neuroaxonal dystrophy
Neurodegeneration
Neurofibrillary tangles
PLA2G6-associated disorders
α-synuclein

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Lewy Bodies in Conditions other than Disorders of α-Synuclein

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Keywords

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