Levodopa inhibits habit-learning in Parkinson's disease

Hannah Fuhrer, Andreas Kupsch, Thomas D. Hälbig, Ute A. Kopp, Peter Scherer, Doreen Gruber

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Mixed dopaminergic medication, comprising dopamine agonists and levodopa, may affect habit-learning in patients with Parkinson's disease (PD). However, the specific impact of levodopa on this effect is unknown. We assessed habit-learning in 20 non-demented PD-patients both with and without levodopa. We observed intact habit-learning in PD-patients OFF-medication. In contrast, the administration of 200 mg of levodopa impaired habit-learning. We conclude that potential deficits in habit-learning in PD may be attributed to the intake of levodopa.

Original languageEnglish
Pages (from-to)147-151
Number of pages5
JournalJournal of Neural Transmission
Volume121
Issue number2
DOIs
StatePublished - Feb 2014
Externally publishedYes

Keywords

  • Cognition
  • Habit-learning
  • Levodopa
  • Parkinson's disease

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