Leukocytes, Thrombosis, and Unstable Angina

Michel de Lorgeril, Jean Gilles Latour, Valentin Fuster, James H. Chesebro

Research output: Contribution to journalLetterpeer-review

10 Scopus citations


To the Editor: The editorial by Fuster and Chesebro (Oct. 16 issue)1 emphasized the importance of the thrombotic process in unstable angina. Platelet activation is an important event in arterial thrombosis, and thrombosis has been associated with abnormal platelet function and composition. However, risk factors for atherosclerosis, such as dietary saturated fats, hyperlipidemia, hypertension, and smoking, which promote platelet activation and thrombosis, also interact with leukocytes.2 3 4 5 Stimulation of leukocytes results in the release of platelet-activating factor and chemotactic and vasospastic substances (leukotrienes and thromboxanes), which may be involved in acute coronary events. In recent years, it has become clear that…

Original languageEnglish
Pages (from-to)1161
Number of pages1
JournalNew England Journal of Medicine
Issue number18
StatePublished - 30 Apr 1987


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