Leukocyte migration inhibitory factor production by activated lymphocytes representing immunological memory or virus-receptor interaction: Response of T cell subsets to Epstein-Barr virus nuclear antigen, response of B cells to UV in activated Epstein-Barr virus

Robert Szigeti, Maria Grazia Masucci, Giuseppe Masucci, Pierre Åman, George Klein, Eva Klein

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Both T and B lymphocytes are known to produce leukocyte migration inhibitory factor (LIF) after appropriate activation. We showed that EBV nuclear antigen (EBNA) triggered T cells for LIF production in an immunologically specific way: only T cells of seropositive individuals responded. Both Fc receptor positive and negative T cells produced LIF, and the presence of macrophages was necessary. The virus itself activated B cells independently of the serological status of the donors, thus the function was not based on immunological memory. This phenomenon was independent of the transforming capacity of the virus, because UV-inactivated virus also elicited LIF production by B lymphocytes. This triggering seems to be the consequence of the virus-receptor interaction on the cell surface.

Original languageEnglish
Pages (from-to)267-273
Number of pages7
JournalImmunology Letters
Volume9
Issue number5
DOIs
StatePublished - 1985
Externally publishedYes

Keywords

  • Epstein-Barr virus
  • Epstein-Barr virus nuclear antigen
  • activated B cells
  • activated T cells
  • leukocyte migration inhibitory factor

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