Leukemia following treatment of germ cell tumors in man

J. R. Redman; D. Vugrin; Z. A. Arlin; T. S. Gee; S. J. Kempin; J. H. Godbold; D. Schottenfeld; B. D. Clarkson

doi:10.1200/JCO.1984.2.10.1080

Leukemia following treatment of germ cell tumors in man

J. R. Redman, D. Vugrin, Z. A. Arlin, T. S. Gee, S. J. Kempin, J. H. Godbold, D. Schottenfeld, B. D. Clarkson

Icahn School of Medicine at Mount Sinai

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Abstract

We investigated the incidence of leukemia occurring subsequently to the treatment of germ cell tumors in men at our institution over a 30-year interval and found four patients with acute nonlymphocytic leukemia (ANLL) and one patient with chronic myelomonocytic leukemia. The relative risk (observed/expected cases) estimates for the development of leukemia ranged from 13.7 (P = .0005) in the total population to 50.1 (P = .0001) in the group treated with cytotoxic agents alone. All three patients with ANLL treated with contemporary antileukemic therapy had complete responses, with survivals of 7, 29, and 133 + months. In a review of the literature, 14 additional cases of germ cell tumors were found in which the men subsequently developed leukemia. It is concluded that leukemia following germ cell tumors is increased in incidence and is likely to be treatment induced. Complete responses and long-term survival are possible in secondary leukemia and aggressive antileukemic therapy should be given.

Original language	English
Pages (from-to)	1080-1087
Number of pages	8
Journal	Journal of Clinical Oncology
Volume	2
Issue number	10
DOIs	https://doi.org/10.1200/JCO.1984.2.10.1080
State	Published - 1984

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title = "Leukemia following treatment of germ cell tumors in man",

abstract = "We investigated the incidence of leukemia occurring subsequently to the treatment of germ cell tumors in men at our institution over a 30-year interval and found four patients with acute nonlymphocytic leukemia (ANLL) and one patient with chronic myelomonocytic leukemia. The relative risk (observed/expected cases) estimates for the development of leukemia ranged from 13.7 (P = .0005) in the total population to 50.1 (P = .0001) in the group treated with cytotoxic agents alone. All three patients with ANLL treated with contemporary antileukemic therapy had complete responses, with survivals of 7, 29, and 133 + months. In a review of the literature, 14 additional cases of germ cell tumors were found in which the men subsequently developed leukemia. It is concluded that leukemia following germ cell tumors is increased in incidence and is likely to be treatment induced. Complete responses and long-term survival are possible in secondary leukemia and aggressive antileukemic therapy should be given.",

author = "Redman, {J. R.} and D. Vugrin and Arlin, {Z. A.} and Gee, {T. S.} and Kempin, {S. J.} and Godbold, {J. H.} and D. Schottenfeld and Clarkson, {B. D.}",

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AU - Redman, J. R.

AU - Vugrin, D.

AU - Arlin, Z. A.

AU - Gee, T. S.

AU - Kempin, S. J.

AU - Godbold, J. H.

AU - Schottenfeld, D.

AU - Clarkson, B. D.

PY - 1984

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N2 - We investigated the incidence of leukemia occurring subsequently to the treatment of germ cell tumors in men at our institution over a 30-year interval and found four patients with acute nonlymphocytic leukemia (ANLL) and one patient with chronic myelomonocytic leukemia. The relative risk (observed/expected cases) estimates for the development of leukemia ranged from 13.7 (P = .0005) in the total population to 50.1 (P = .0001) in the group treated with cytotoxic agents alone. All three patients with ANLL treated with contemporary antileukemic therapy had complete responses, with survivals of 7, 29, and 133 + months. In a review of the literature, 14 additional cases of germ cell tumors were found in which the men subsequently developed leukemia. It is concluded that leukemia following germ cell tumors is increased in incidence and is likely to be treatment induced. Complete responses and long-term survival are possible in secondary leukemia and aggressive antileukemic therapy should be given.

AB - We investigated the incidence of leukemia occurring subsequently to the treatment of germ cell tumors in men at our institution over a 30-year interval and found four patients with acute nonlymphocytic leukemia (ANLL) and one patient with chronic myelomonocytic leukemia. The relative risk (observed/expected cases) estimates for the development of leukemia ranged from 13.7 (P = .0005) in the total population to 50.1 (P = .0001) in the group treated with cytotoxic agents alone. All three patients with ANLL treated with contemporary antileukemic therapy had complete responses, with survivals of 7, 29, and 133 + months. In a review of the literature, 14 additional cases of germ cell tumors were found in which the men subsequently developed leukemia. It is concluded that leukemia following germ cell tumors is increased in incidence and is likely to be treatment induced. Complete responses and long-term survival are possible in secondary leukemia and aggressive antileukemic therapy should be given.

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Leukemia following treatment of germ cell tumors in man

Abstract

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