Leucylglycinamide released from oxytocin by human uterine enzyme

Roderich Walter, H. Shlank, J. D. Glass, I. L. Schwartz, T. D. Kerenyi

Research output: Contribution to journalArticlepeer-review

225 Scopus citations

Abstract

Uteri of pregnant and nonpregnant women contain enzymic activities which inactivate oxytocin. A potent enzyme, which has been partially purified from uterine homogenates, cleaves the prolyl-leucyl peptide bond of oxytocin. This finding associates for the first time the release of the dipeptide lencylglycinamide with the degradation of neurohypophyseal hormones.

Original languageEnglish
Pages (from-to)827-829
Number of pages3
JournalScience
Volume173
Issue number3999
DOIs
StatePublished - 1971

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