Leucine-rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants

Keyphrases

• GTPase Activity 100%
• Leucine-rich Repeat Kinase 2 (LRRK2) 100%
• Idiopathic Parkinson's Disease 100%
• R1441C 100%
• PARK8 100%
• Kinase Activity 33%
• Parkinson's Disease 27%
• GTP Hydrolysis 16%
• GTPase Domain 16%
• GTPase 11%
• Disease-causing mutations 11%
• Hydrolytic Activity 11%
• Biochemical Characteristics 5%
• Epitope 5%
• Transgenic Mice 5%
• Lung 5%
• Cell Culture 5%
• Transgenic 5%
• Neuronal Dysfunction 5%
• Mouse Brain 5%
• Cultured Cells 5%
• Mitogen-activated Protein Kinase 5%
• GTP Binding 5%
• Enzymatic Activity 5%
• Transfected Cells 5%
• Neuronal Function 5%
• Functional Domain 5%
• Sporadic Form 5%
• Family Forms 5%
• Familial mutations 5%

Biochemistry, Genetics and Molecular Biology

• Kinase 100%
• Phosphotransferase 100%
• Leucine-Rich Repeat 100%
• GTPase 100%
• Guanosine Triphosphate 11%
• Enzymatic Hydrolysis 11%
• Enzyme Activity 3%
• Transgenic Mouse 3%
• Transgenics 3%
• Cell Culture 3%

Neuroscience

• Leucine Rich Repeat Kinase 2 100%
• GTPase 100%
• Familial Parkinson's Disease 100%
• Kinase 44%
• Parkinson's Disease 22%
• Guanosine Triphosphate 16%
• Cell Culture 5%
• Epitope 5%
• Enzyme Activity 5%
• Mouse Brain 5%