Lethal Giant Lineage Tracing: Mutating Locally, Acting Globally

Aslam Abbasi Akhtar, Hannah Park, Joshua J. Breunig

Research output: Contribution to journalShort surveypeer-review


The generation of neurons and glia from radial glia progenitors is critical to proper neocortical development but the mechanisms regulating their deterministic production are unclear. In this issue of Neuron, Beattie et al. (2017) use elegant MADM-based lineage tracing to demonstrate cell-intrinsic and global functions for Lgl1 during neocortical development.

Original languageEnglish
Pages (from-to)417-420
Number of pages4
Issue number3
StatePublished - 3 May 2017
Externally publishedYes


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