Lessons from TGF-β transgenic mice

Erwin P. Böttinger, Jeffrey B. Kopp

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations

Abstract

Aberrant expression of TGF-β and/or receptor/signaling function is present in a wide variety of disease processes. Overexpression of TGF-β isoforms in transgenic mice using tissue-specific promoters has provided model systems to study the effects of increased activity of TGF-β in the intact organism. We will review the pertinent features of some of these models, and discuss new insights provided by these studies into regulation and role of TGF-β in health and disease.

Original languageEnglish
Pages (from-to)154-160
Number of pages7
JournalMineral and Electrolyte Metabolism
Volume24
Issue number2-3
DOIs
StatePublished - Mar 1998
Externally publishedYes

Keywords

  • Development
  • Disease
  • Fibrosis
  • Inflammation
  • TGF-β
  • Transgenic mice

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